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Observational Study
. 2020 May 25:2020:9206703.
doi: 10.1155/2020/9206703. eCollection 2020.

Circulating Matrix Metalloproteinase-28 Levels Are Related to GRACE Scores and Short-Term Outcomes in Patients with Acute Myocardial Infarction

Ke Zhou  1   2 , Yuanmin Li  3 , Yawei Xu  1 , Rong Guo  2
Affiliations
Observational Study

Circulating Matrix Metalloproteinase-28 Levels Are Related to GRACE Scores and Short-Term Outcomes in Patients with Acute Myocardial Infarction

Ke Zhou et al. Biomed Res Int. .

Abstract

Objective: To investigate the relationship between the level of matrix metalloproteinase-28 (MMP-28) in patients with acute myocardial infarction (AMI) and the global registry of acute coronary events (GRACE) scores as well as their short-term prognosis.

Methods: Two hundred eleven patients with AMI were enrolled, and their basic clinical characteristics were collected for determining the GRACE score. We measured the plasma levels of MMP-28 and other biomarkers in the study population. The association of MMP-28 levels with cardiac events and cardiac deaths occurring within 30 days of discharge was evaluated with multivariable Cox proportional hazard models.

Results: The MMP-28 levels were significantly higher in patients with acute ST-elevation myocardial infarction (STEMI) than in patients with non-ST-elevation myocardial infarction (NSTEMI) (P < 0.01). Correlation analysis showed that the level of MMP-28 was positively correlated with the GRACE score in patients with AMI (R 2 = 0.366, P < 0.05). Cox multivariate regression results showed that MMP-28 was associated with cardiovascular events during the hospitalization and 30 days after discharge (P < 0.01). In addition, Kaplan-Meier analysis showed that cardiac events and deaths were significantly higher in patients with MMP-28 ≥ 1.21 ng/mL (all P < 0.01).

Conclusion: There is a correlation between the plasma MMP-28 level and GRACE score in patients with AMI. MMP-28 is also associated with cardiovascular events and cardiovascular deaths during the hospitalization of patients and within 30 days of discharge.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
MMP-28 levels in the groups with different risks and the correlation between MMP-28 and GRACE scores. (a) Plasma MMP-28 levels in the groups with different risks. (b) MMP-28 levels were positively correlated with GRACE scores in patients with acute myocardial infarction. ∗P < 0.05.
Figure 2
Figure 2
Correlation between the levels of hs-CRP, hs-cTnT, NT-proBNP, LVEF, and MMP-28. Plasma MMP-28 was negatively correlated with hs-CRP (a), hs-cTNT (b), NT-proBNP (c), and LVEF (d) (P < 0.001).
Figure 3
Figure 3
Kaplan–Meier analysis. (a) Kaplan–Meier curve showing the incidence of cardiac events, within 30 days after discharge in patients with acute myocardial infarction. (b) Patients with high MMP-28 levels had significantly higher rates of cardiac death than patients with low MMP-28 levels.
See this image and copyright information in PMC

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