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. 2018 Dec 31;5(1):153.
doi: 10.18063/ijb.v5i1.153. eCollection 2019.

Biofabrication offers future hope for tackling various obstacles and challenges in tissue engineering and regenerative medicine: A Perspective

Tanveer Ahmad Mir  1   2   3 , Shintaroh Iwanaga  1 , Taketoshi Kurooka  1 , Hideki Toda  1 , Shinji Sakai  4 , Makoto Nakamura  1   2
Affiliations

Biofabrication offers future hope for tackling various obstacles and challenges in tissue engineering and regenerative medicine: A Perspective

Tanveer Ahmad Mir et al. Int J Bioprint. .

Erratum in

  • ERRATUM.
    [No authors listed] [No authors listed] Int J Bioprint. 2020 Sep 17;6(4):309. doi: 10.18063/ijb.v6i4.309. eCollection 2020. Int J Bioprint. 2020. PMID: 33102924 Free PMC article.

Abstract

Biofabrication is an emerging multidisciplinary field that makes a revolutionary impact on the researches on life science, biomedical engineering, and both basic and clinical medicine, has progressed tremendously over the past few years. Recently, there has been a big boom in three-dimensional (3D) printing or additive manufacturing (AM) research worldwide, and there is a significant increase not only in the number of researchers turning their attention to AM but also publications demonstrating the potential applications of 3D printing techniques in multiple fields. Biofabrication and bioprinting hold great promise for the innovation of engineering-based organ replacing medicine. In this mini review, various challenges in the field of tissue engineering are focused from the point of view of the biofabrication - strategies to bridge the gap between organ shortage and mission of medical innovation research seek to achieve organ-specific treatments or regenerative therapies. Four major challenges are discussed including (i) challenge of producing organs by AM, (ii) digitalization of tissue engineering and regenerative medicine, (iii) rapid production of organs beyond the biological natural course, and (iv) extracorporeal organ engineering.

Keywords: Biofabrication; bioprinting; regenerative medicine; tissue engineering.

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Figures

Figure 1
Figure 1
The sketch shows a schematic drawing of the potential strategy for digitalization of tissue engineering and regenerative medicine.
Figure 2
Figure 2
The sketch shows a schematic drawing of the strategy of rapid production of the organs beyond the biological natural course.
Figure 3
Figure 3
The sketch shows a schematic drawing of the general culture strategy and organ perfusion bioreactor technology.
See this image and copyright information in PMC

References

    1. Robert J M, Christopher M C. Pathophysiology and clinical evaluation of acute heart failure. Nat Rev Cardiol. 2016;13(1):28–35. https://doi.org/10.1038/nrcardio.2015.134. - PubMed
    1. Wouters O J, O'Donoghue D J, Ritchie J. Early chronic kidney disease:Diagnosis, management and models of care. Nat Rev Nephrol. 2015;11(8):491–502. https://doi.org/10.1038/nrneph.2015.85. - PMC - PubMed
    1. Shiv K S, Ashok C. Acute–on–chronic liver failure:Terminology, mechanisms and management. Nat Rev Gastroenterol Hepatol. 2016;13(3):131–149. https://doi.org/10.1038/nrgastro.2015.219. - PubMed
    1. Pfeifer R, Teuben M, Andruszkow H, et al. Mortality patterns in patients with multiple trauma:A systematic review of autopsy studies. PLoS One. 2016;11(2):e0148844. https://doi.org/10.1371/journal.pone.0148844. - PMC - PubMed
    1. Lelubre C, Vincent J L. Mechanisms and treatment of organ failure in sepsis. Nat Rev Nephrol. 2018;14(7):417–427. https://doi.org/10.1038/s41581-018-0005-7. - PubMed

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