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Observational Study
. 2020 Oct 25;58(11):1951-1957.
doi: 10.1515/cclm-2020-0417.

Monocyte distribution width (MDW) as a screening tool for sepsis in the Emergency Department

Luisa Agnello  1 , Giulia Bivona  1 , Matteo Vidali  2 , Concetta Scazzone  1 , Rosaria Vincenza Giglio  1 , Giorgia Iacolino  1 , Alessandro Iacona  1 , Silvia Mancuso  1 , Anna Maria Ciaccio  3 , Bruna Lo Sasso  1   4 , Marcello Ciaccio  1   4
Affiliations
Observational Study

Monocyte distribution width (MDW) as a screening tool for sepsis in the Emergency Department

Luisa Agnello et al. Clin Chem Lab Med. .

Abstract

Objectives The diagnosis of sepsis in the Emergency Department (ED) is challenging and a reliable biomarker is needed. The current study aimed to evaluate the diagnostic accuracy of monocyte distribution width (MDW) for the early identification of sepsis in the ED. Methods We performed a large observational study including consecutive adult patients (≥18 years of age) presenting to the ED between September and November 2019, with an order for complete blood count (CBC) evaluation. A total of 2,215 patients were enrolled and classified based on Sepsis-2 criteria as the control group (1,855), infection group (172), Systemic Inflammatory Response Syndrome (SIRS) group (100), and sepsis group (88). Results MDW levels were higher in patients with sepsis than in all other groups (p<0.001). ROC curve analysis showed an optimal diagnostic accuracy of MDW for sepsis prediction at a cut-off point of 23.5, with an AUC of 0.964, sensitivity and specificity of 0.920 and 0.929, respectively. Conclusions Our findings encourage further investigation to validate the use of MDW as a screening tool for the early identification of patients at risk of sepsis in the ED.

Keywords: Emergency Department (ED); infection; monocyte distribution width (MDW); monocytes; screening; sepsis.

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