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Review
. 2020 Sep:153:103032.
doi: 10.1016/j.critrevonc.2020.103032. Epub 2020 Jun 15.

Which type of cancer patients are more susceptible to the SARS-COX-2: Evidence from a meta-analysis and bioinformatics analysis

Bolin Wang  1 , Yan Huang  2
Affiliations
Review

Which type of cancer patients are more susceptible to the SARS-COX-2: Evidence from a meta-analysis and bioinformatics analysis

Bolin Wang et al. Crit Rev Oncol Hematol. 2020 Sep.

Abstract

Objective: Numerous studies have reported that patients with cancer seem to be more likely to be diagnosed with COVID-19. However, it is still unknown the prevalence of different types of cancer in patients with COVID-19. Therefore, this study will explore which type of cancer patients are more susceptible to the SARS-COX-2.

Methods: Eligible studies were identified by searching several electronic databases for relevant studies published before April 28, 2020. The language was restricted to English or Chinese. The meta-analysis was performed using Stata 12.0. The GEPIA database evaluated the expression of SARS-COX-2 infection key genes in different types of normal and tumor samples.

Results: A total of 6 studies, including 205 patients, were identified to be eligible for this meta-analysis. Among the cancer patients infected by SARS-COX-2, the proportion of patients with the lung, colorectal, breast, esophagus, bladder, pancreatic and cervical cancer were 24.7 %, 20.5 %, 13.0 %, 7.6 %,7.3 %,6.1 %,and 6.0 %, respectively. These findings were also corroborated by the results of the GEPIA database.

Conclusion: Compared with other types of cancer, lung cancer and colorectal cancer are more susceptible to SARS-COX-2 infection.

Keywords: COVID-19; Cancer; Meta-analysis; SARS-CoV-2.

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Figures

Fig. 1
Fig. 1
Flow diagram of the literature search and selection process in the meta-analysis.
Fig. 2
Fig. 2
The prevalence of different types of cancer in patients with COVID-19.
Fig. 3
Fig. 3
The expression of ACE2 and TMPRss2 in cancer and normal tissue. LUAD: Lung adenocarcinoma; LUSC: Lung squamous cell carcinoma; BRCA: Breast invasive carcinoma ;COAD: Colon adenocarcinoma; READ: Rectum adenocarcinoma; ESCA: Esophageal carcinoma; PAAD: Pancreatic adenocarcinoma; BLCA: Bladder Urothelial Carcinoma; CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma; T: Cancer tissue; N: Normal tissue.
See this image and copyright information in PMC

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