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Comment
. 2020 Sep;40(9):1912-1914.
doi: 10.1177/0271678X20938146. Epub 2020 Jun 29.

Leaky memories: Impact of APOE4 on blood-brain barrier and dementia

Wenlu Li  1 , Eng H Lo  1
Affiliations
Comment

Leaky memories: Impact of APOE4 on blood-brain barrier and dementia

Wenlu Li et al. J Cereb Blood Flow Metab. 2020 Sep.

Abstract

A new study suggests that the leading genetic risk factor for Alzheimer's disease, apolipoprotein E4 (APOE4), is linked to blood-brain barrier breakdown and subsequent cognitive decline. These findings broaden our understanding of how cerebrovascular mechanisms contribute to cognitive impairment and should stimulate new directions for pursuing therapeutic approaches for Alzheimer's disease and related dementias.

Keywords: Alzheimer’s disease; apolipoprotein E4; blood–brain barrier; dementia; pericyte degeneration.

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Comment on

  • APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline.
    Montagne A, Nation DA, Sagare AP, Barisano G, Sweeney MD, Chakhoyan A, Pachicano M, Joe E, Nelson AR, D'Orazio LM, Buennagel DP, Harrington MG, Benzinger TLS, Fagan AM, Ringman JM, Schneider LS, Morris JC, Reiman EM, Caselli RJ, Chui HC, Tcw J, Chen Y, Pa J, Conti PS, Law M, Toga AW, Zlokovic BV. Montagne A, et al. Nature. 2020 May;581(7806):71-76. doi: 10.1038/s41586-020-2247-3. Epub 2020 Apr 29. Nature. 2020. PMID: 32376954 Free PMC article.

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