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Review
. 2020 Aug;47(3):345-358.
doi: 10.1016/j.ucl.2020.04.007.

Adjuvant Therapy for Localized High-Risk Renal Cell Carcinoma

Erika Wood  1 , Nicholas Donin  2 , Brian Shuch  3
Affiliations
Review

Adjuvant Therapy for Localized High-Risk Renal Cell Carcinoma

Erika Wood et al. Urol Clin North Am. 2020 Aug.

Abstract

This article reviews the use of adjuvant therapies for prevention of recurrence following resection of clinically localized renal cell carcinoma (RCC). Clinical trials evaluating adjuvant therapy for RCC have focused primarily on the use of tyrosine kinase inhibitors and mammalian target of rapamycin inhibitors, which had improved outcome in patients with metastatic disease. However, all but 1 trial found no difference in disease-free survival in the adjuvant setting and none improved overall survival.

Keywords: Adjuvant; Carcinoma; Chemotherapy; Immunotherapy; Molecular targeted therapy; Recurrence; Renal cell.

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Conflict of interest statement

Disclosure The authors have nothing to disclose.