Hepatoprotective effects of silymarin coated gold nanoparticles in experimental cholestasis

Abstract

The present study reports the green synthesis of hybrid organic-inorganic gold nanocomposites using silymarin as reducing and capping agent. The structure of the silymarin loaded gold nanoparticles was investigated by using the appropriate analysis tools such as UV-Vis and Fourier-transform infrared spectroscopy (FTIR), and Transmission electron microscopy (TEM) techniques. TEM micrographs demonstrated that the gold nanoparticles were spherical in shape, well distributed and their mean size was about 10 nm. The in vivo hepatoprotective and antifibrogenic properties after bile duct ligation in rats of the silymarin coated gold nanoparticles were assessed. The changes regarding the blood tests and the liver histopathology were compared to the standard administration of silymarin. Silymarin loaded gold nanoparticles improved liver function, reduced cholestasis and oxidative stress parameters, with the increase of antioxidant support, and reduced inflammation and fibrosis in the liver of rats with extrahepatic cholestasis.

Keywords: Cholestasis; Gold nanoparticles; Hepatoprotective agent; Silymarin.