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. 2020 Sep;125(3):e334-e336.
doi: 10.1016/j.bja.2020.05.056. Epub 2020 Jun 10.

Does prolonged propofol sedation of mechanically ventilated COVID-19 patients contribute to critical illness myopathy?

Per-Arne Lönnqvist  1 , Max Bell  2 , Torbjörn Karlsson  3 , Lars Wiklund  3 , Anna-Stina Höglund  2 , Lars Larsson  2
Affiliations

Does prolonged propofol sedation of mechanically ventilated COVID-19 patients contribute to critical illness myopathy?

Per-Arne Lönnqvist et al. Br J Anaesth. 2020 Sep.
No abstract available

Keywords: COVID-19; ICU; critical illness myopathy; myopathy; propofol.

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Figures

Fig 1
Fig 1
Intracellular localisation of serum proteins in animals exposed to propofol. (a) Shows a section at Day 1 from an animal that received a high-dose propofol treatment. Serum proteins (green) are present in small capillaries and between individual muscle cells. (b) A section after 5 days of treatment shows serum proteins in the cytoplasm of a few necrotic muscle cells. An increased number of nuclei (blue) are also present. (c) A low magnification displays some muscle cells with internal serum protein (arrows). (d) A high magnification of an area from (c). (e) (f) TUNEL (Terminal deoxynucleotidyl transferase dUTP nick end labeling) staining shows apoptotic nuclei in sections from musculus. biceps femoris from a high-dose propofol-treated animal at Day 1 and Day 5.
See this image and copyright information in PMC

Comment in

  • Propofol infusion syndrome in severe COVID-19.
    Lucchetta V, Bonvicini D, Ballin A, Tiberio I. Lucchetta V, et al. Br J Anaesth. 2020 Nov;125(5):e441-e442. doi: 10.1016/j.bja.2020.08.020. Epub 2020 Aug 24. Br J Anaesth. 2020. PMID: 32912604 Free PMC article. No abstract available.

References

    1. Grasselli G., Zangrillo A., Zanella A. Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy Region, Lombardia, Italy. JAMA. 2020;323:1574–1581. - PMC - PubMed
    1. Larsson L., Friedrich O. Critical illness myopathy (cim) and ventilator-induced diaphragm muscle dysfunction (vidd): acquired myopathies affecting contractile proteins. Compr Physiol. 2016;7:105–112. - PubMed
    1. Llano-Diez M., Renaud G., Andersson M. Mechanisms underlying ICU muscle wasting and effects of passive mechanical loading. Crit Care. 2012;16 - PMC - PubMed
    1. Ochala J., Gustafson A.M., Diez M.L. Preferential skeletal muscle myosin loss in response to mechanical silencing in a novel rat intensive care unit model: underlying mechanisms. J Physiol. 2011;589:2007–2026. - PMC - PubMed
    1. Norman H., Nordquist J., Andersson P. Impact of post-synaptic block of neuromuscular transmission, muscle unloading and mechanical ventilation on skeletal muscle protein and mRNA expression. Pflugers Arch. 2006;453:53–66. - PubMed