Gut microbiota orchestrates PTH action in bone: role of butyrate and T cells

Affiliations

¹ Inserm Unit 1018, Team 5, CESP, Hôpital Paul Brousse, Paris-Sud University (UPS) and Versailles Saint-Quentin-en-Yvelines University (Paris-Ile-de-France-Ouest University, UVSQ), Villejuif, France; Department of Nephrology, Ambroise Paré University Hospital, APHP, Boulogne-Billancourt/Paris, France.
² Inserm Unit 1018, Team 5, CESP, Hôpital Paul Brousse, Paris-Sud University (UPS) and Versailles Saint-Quentin-en-Yvelines University (Paris-Ile-de-France-Ouest University, UVSQ), Villejuif, France. Electronic address: tilman.drueke@inserm.fr.

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Comment

Ziad A Massy et al. Kidney Int. 2020 Aug.

Free article

. 2020 Aug;98(2):269-272.

doi: 10.1016/j.kint.2020.03.004. Epub 2020 Mar 25.

¹ Inserm Unit 1018, Team 5, CESP, Hôpital Paul Brousse, Paris-Sud University (UPS) and Versailles Saint-Quentin-en-Yvelines University (Paris-Ile-de-France-Ouest University, UVSQ), Villejuif, France; Department of Nephrology, Ambroise Paré University Hospital, APHP, Boulogne-Billancourt/Paris, France.
² Inserm Unit 1018, Team 5, CESP, Hôpital Paul Brousse, Paris-Sud University (UPS) and Versailles Saint-Quentin-en-Yvelines University (Paris-Ile-de-France-Ouest University, UVSQ), Villejuif, France. Electronic address: tilman.drueke@inserm.fr.

No abstract available

Keywords: bone; mineral metabolism; parathyroid hormone.

Comment on

Parathyroid hormone-dependent bone formation requires butyrate production by intestinal microbiota.
Li JY, Yu M, Pal S, Tyagi AM, Dar H, Adams J, Weitzmann MN, Jones RM, Pacifici R. Li JY, et al. J Clin Invest. 2020 Apr 1;130(4):1767-1781. doi: 10.1172/JCI133473. J Clin Invest. 2020. PMID: 31917685 Free PMC article.
PTH induces bone loss via microbial-dependent expansion of intestinal TNF⁺ T cells and Th17 cells.
Yu M, Malik Tyagi A, Li JY, Adams J, Denning TL, Weitzmann MN, Jones RM, Pacifici R. Yu M, et al. Nat Commun. 2020 Jan 24;11(1):468. doi: 10.1038/s41467-019-14148-4. Nat Commun. 2020. PMID: 31980603 Free PMC article.