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Review
. 2021 Jan;106(1):350-358.
doi: 10.1113/EP088512. Epub 2020 Jul 14.

Integrative crosstalk between hypoxia and the cold: Old data and new opportunities

Hendrik Mugele  1 , Samuel J Oliver  2 , Daniel Gagnon  3   4 , Justin S Lawley  1
Affiliations
Free article
Review

Integrative crosstalk between hypoxia and the cold: Old data and new opportunities

Hendrik Mugele et al. Exp Physiol. 2021 Jan.
Free article

Abstract

New findings: What is the topic of this review? The aim was to examine the influence of hypoxia on thermoregulatory and cardiovascular control in the cold. What advances does it highlight? Exposure to hypoxia seems to alter both thermoregulatory and cardiovascular control, but these conclusions are based on limited data, and this review highlights the need for future research in this area.

Abstract: Cold stress and hypoxia have been the subject of research for decades; however, humans often encounter these stressors together, such as in the alpine environment. Therefore, this review summarizes previous data with respect to the influence of hypoxia on thermoregulatory and cardiovascular control in the cold and presents new ideas for the future. Altogether, little to no evidence is available on the integrative and adaptive mechanisms by which the human body regulates heat conservation, oxygen delivery and maintenance of blood pressure.

Keywords: cardiovascular physiology; cold and hypoxia; cutaneous vasoconstriction; thermogenesis.

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References

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