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. 2021 Sep;23(9):877-883.
doi: 10.1080/10286020.2020.1787388. Epub 2020 Jun 30.

1,10-seco guaianolide-type sesquiterpenoids from Chrysanthemum indicum

Gui-Min Xue  1   2 , Jin-Feng Xue  1   2 , Chen-Guang Zhao  1   2 , Zhen-Zhu Zhao  1   2 , Yan-Le Zhi  1   2 , Kun Du  1   2 , Han-Wei Li  1 , Yan-Jun Sun  1   2 , Wei-Sheng Feng  1   2
Affiliations

1,10-seco guaianolide-type sesquiterpenoids from Chrysanthemum indicum

Gui-Min Xue et al. J Asian Nat Prod Res. 2021 Sep.

Abstract

ABSTACTA chemical investigation of the whole plant of traditional Chinese medicine, Chrysanthemum indicum L., led to the discovery of six guaianolide-type sesquiterpenoids 1-6 with a 1,10-splited skeleton. The structure of the new compound 1 was established by extensive analysis of UV, IR, MS, NMR and ECD data. Compounds 3-6 are mutually stereoisomers with four chiral centers and their absolute configurations were determined by comparison of ECD spectra. The anti-inflammatory effects of these isolates on lipopolysaccharide (LPS)-induced nitric oxide (NO) were investigated in RAW 264.7 cells. Results showed that most of the compounds displayed NO production inhibitory activities with IC50 values ranged from 3.54 to 8.17 μM.

Keywords: anti-inflammation; sesquiterpenoid; 1,10-seco-guaianolide; Chrysanthemum indicum.

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