Clinical Trial
doi: 10.1007/BF01072499.
Adrenocorticosteroid therapy in alcoholic hepatitis. A prospective, double-blind randomized study
- PMID: 326034
- DOI: 10.1007/BF01072499
Item in Clipboard
Clinical Trial
Adrenocorticosteroid therapy in alcoholic hepatitis. A prospective, double-blind randomized study
Am J Dig Dis.
1977 Jun.
Abstract
In a prospective, randomized, double-blind study of prednisolone therapy of acute alcoholic hepatitis, 39% of the total group of 28 patients died. Mortality and cumulative survival were similar in steroid- and placebo-treated patients. After 14 days of therapy, the serum albumin concentration and white blood count were significantly higher in the steroid group, but all other parameters were similar. An increased risk of fungal infection appeared to be associated with steroid therapy.
Similar articles
-
Alcoholic hepatitis. Natural history and evaluation of prednisolone therapy.Ann Intern Med. 1971 Mar;74(3):311-21. doi: 10.7326/0003-4819-74-3-311. Ann Intern Med. 1971. PMID: 4928161 Clinical Trial. No abstract available.
-
Controlled prospective trial of corticosteroid therapy in active chronic hepatitis.Q J Med. 1971 Apr;40(158):159-85. doi: 10.1093/oxfordjournals.qjmed.a067264. Q J Med. 1971. PMID: 4933363 Clinical Trial. No abstract available.
-
Double-blind controlled trial of prednisolone therapy in patients with severe acute alcoholic hepatitis and spontaneous encephalopathy.Gastroenterology. 1980 Mar;78(3):524-9. Gastroenterology. 1980. PMID: 6985881 Clinical Trial.
-
Corticosteroids and occurrence of and mortality from infections in severe alcoholic hepatitis: a meta-analysis of randomized trials.Liver Int. 2016 May;36(5):721-8. doi: 10.1111/liv.12939. Epub 2015 Sep 14. Liver Int. 2016. PMID: 26279269 Review.
-
Treatment of chronic hepatitis.Prog Liver Dis. 1972;4:419-32. Prog Liver Dis. 1972. PMID: 4569006 Review. No abstract available.
Cited by
-
Current concepts and controversies in the treatment of alcoholic hepatitis.World J Gastroenterol. 2006 Nov 21;12(43):6909-21. doi: 10.3748/wjg.v12.i43.6909. World J Gastroenterol. 2006. PMID: 17109510 Free PMC article. Review.
-
Alcoholic Hepatitis.Curr Treat Options Gastroenterol. 2001 Dec;4(6):511-516. doi: 10.1007/s11938-001-0016-4. Curr Treat Options Gastroenterol. 2001. PMID: 11696277
-
Controlled trial of methylprednisolone therapy in severe acute alcoholic hepatitis.Gut. 1982 Jan;23(1):75-9. doi: 10.1136/gut.23.1.75. Gut. 1982. PMID: 7035299 Free PMC article. Clinical Trial.
-
Early mortality of alcoholic hepatitis: a review of data from placebo-controlled clinical trials.World J Gastroenterol. 2010 May 21;16(19):2435-9. doi: 10.3748/wjg.v16.i19.2435. World J Gastroenterol. 2010. PMID: 20480532 Free PMC article. Review.
-
Treatment of decompensated alcoholic liver disease.Int J Hepatol. 2011;2011:219238. doi: 10.4061/2011/219238. Epub 2011 Jul 12. Int J Hepatol. 2011. PMID: 21994849 Free PMC article.