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Review
. 2020 Jun 27;13(13):2891.
doi: 10.3390/ma13132891.

A Bibliometric Review of Artificial Extracellular Matrices Based on Tissue Engineering Technology Literature: 1990 through 2019

Pilar Simmons  1   2   3 , Taylor McElroy  1   2   3 , Antiño R Allen  1   2   3
Affiliations
Review

A Bibliometric Review of Artificial Extracellular Matrices Based on Tissue Engineering Technology Literature: 1990 through 2019

Pilar Simmons et al. Materials (Basel). .

Abstract

Artificial extracellular matrices (aECMs) are an extension of biomaterials that were developed as in-vitro model environments for tissue cells that mimic the native in vivo target tissues' structure. This bibliometric analysis evaluated the research productivity regarding aECM based on tissue engineering technology. The Web of Science citation index was examined for articles published from 1990 through 2019 using three distinct aECM‑related topic sets. Data were also visualized using network analyses (VOSviewer). Terms related to in-vitro, scaffolds, collagen, hydrogels, and differentiation were reoccurring in the aECM‑related literature over time. Publications with terms related to a clinical direction (wound healing, stem cells, artificial skin, in‑vivo, and bone regeneration) have steadily increased, as have the number of countries and institutions involved in the artificial extracellular matrix. As progress with 3D scaffolds continues to advance, it will become the most promising technology to provide a therapeutic option to repair or replace damaged tissue.

Keywords: artificial extracellular matrix; biomaterials; regeneration; tissue engineering.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Figures

Figure 1
Figure 1
Number of publications and cumulative number of publications for topic set 1(A), topic set 2(B) and topic set 3(C) per year.
Figure 2
Figure 2
Term map for years (a) 1990 through 1999 (b) 2010 through 2019. (a) Term map showing the visualization of 51 terms. Table S1 contains all the terms visualized with their respective occurrence frequencies and averaged citations. (b) Term map showing the visualization of 630 terms. Table S3 contains all the terms visualized with their respective occurrence frequencies and averaged citations.
Figure 3
Figure 3
Term map for years 2010 through 2019. Term map showing the visualization of 79 terms. Table S9 contains all the terms visualized with their respective occurrence frequencies and averaged citations.
Figure 4
Figure 4
World map representing the averaged citations per topic set 1 related papers published 1990 through 2019. Papers may have authors from more than one country denoting international collaboration. Please refer to the color scale for averaged citations. Countries with at least 20 publications are represented.
See this image and copyright information in PMC

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