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Case Reports
. 2020 Jun 30;13(6):e235499.
doi: 10.1136/bcr-2020-235499.

Isolated second-phase diabetes insipidus post-transsphenoidal surgery

Annalisa Montebello  1 , Darryl Portelli  2 , Mark Gruppetta  3
Affiliations
Case Reports

Isolated second-phase diabetes insipidus post-transsphenoidal surgery

Annalisa Montebello et al. BMJ Case Rep. .

Abstract

A 57-year-old woman presented with severe lethargy, dizziness and nausea 1 week after transsphenoidal resection of a growth hormone secreting pituitary adenoma. She was found to have severe hyponatremia of 115 mmol/L. Importantly, she was neurologically intact and clinically euvolaemic. Her fluid intake was restricted and her sodium levels increased to 131 mmol/L over 4 days. She made a full recovery.She was diagnosed with isolated second-phase diabetes insipidus, a state of symptomatic hypoosmolar hyponatremia that usually occurs 7-10 days after transsphenoidal surgery. The sodium levels improve with fluid restriction.

Keywords: metabolic disorders; neurosurgery.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Sodium trends over 4 days of admission with fluid restriction.
See this image and copyright information in PMC

References

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