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. 2020 Aug;30(8):705-707.
doi: 10.1038/s41422-020-0367-9. Epub 2020 Jun 30.

Distinct stem/progenitor cells proliferate to regenerate the trachea, intrapulmonary airways and alveoli in COVID-19 patients

Yinshan Fang  1 , Helu Liu  1 , Huachao Huang  1 , Haiyan Li  2 , Anjali Saqi  3 , Li Qiang  3 , Jianwen Que  4
Affiliations

Distinct stem/progenitor cells proliferate to regenerate the trachea, intrapulmonary airways and alveoli in COVID-19 patients

Yinshan Fang et al. Cell Res. 2020 Aug.
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Distinct proliferating cells in the trachea, intrapulmonary airways and alveoli of COVID-19 patients.
a Proliferating basal cells are enriched in the area where severe damages occur. Note Ki67+ cells are limited to the immediate parabasal layer. b Proliferating basal cells are present in the basal (arrowheads) and immediate parabasal layers where the overlaying club and ciliated are depleted. c Proliferating cells in the intrapulmonary airways include basal cells (arrowheads), club cells (long arrows) and KRT5− SCGB1A1− population (arrows). d Extensive proliferating alveolar type 2 cells (arrows). e Schematics of proliferating epithelial cells in COVID-19 trachea and lung. Note the predominant proliferating cells in the small airways are Lineage Negative Proliferating Cells (LNPCs). In this study tracheas and lungs from five COVID-19 patients were examined. Scale bar, 50 µm.
See this image and copyright information in PMC

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