Mechanism of Traditional Chinese Medicine in Treating Knee Osteoarthritis
- PMID: 32606908
- PMCID: PMC7304682
- DOI: 10.2147/JPR.S247827
Mechanism of Traditional Chinese Medicine in Treating Knee Osteoarthritis
Abstract
Knee osteoarthritis (KOA) is a degenerative disease, making a unique contribution to chronic pain, edema, and limited mobility of knee joint. Traditional Chinese Medicine (TCM) is a common complementary therapy for KOA and has been found effective. The aim of this review is to consolidate the current knowledge about the mechanism of four interventions of TCM: acupuncture, moxibustion, herbs, and massage in treating KOA, and how they alleviate symptoms such as pain, swelling, and dysfunction. Furthermore, this review highlights that four therapies have different mechanisms but all of them can manage KOA through inhibiting inflammation, which indicates that alternative therapies should be considered as a viable complementary treatment for pain management in clinical practice.
Keywords: acupuncture; herbs; knee osteoarthritis; massage; moxibustion.
© 2020 Wang et al.
Conflict of interest statement
The authors declare that there is no conflict of interest regarding the publication of this paper.
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References
-
- Herrero-Beaumont G, Perez-Baos S, Sanchez-Pernaute O, Roman-Blas JA, Lamuedra A, Largo R. Targeting chronic innate inflammatory pathways, the main road to prevention of osteoarthritis progression. Biochem Pharmacol. 2019. - PubMed
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