The Clinical Diagnostic and Prognostic Value of Dickkopf-1 in Cancer

doi:10.2147/CMAR.S254596

Review

. 2020 Jun 8:12:4253-4260.

doi: 10.2147/CMAR.S254596. eCollection 2020.

The Clinical Diagnostic and Prognostic Value of Dickkopf-1 in Cancer

Jie Li¹, Yan Gao¹, Wentao Yue¹

Affiliations

PMID: 32606922
PMCID: PMC7292247
DOI: 10.2147/CMAR.S254596

Review

The Clinical Diagnostic and Prognostic Value of Dickkopf-1 in Cancer

Jie Li et al. Cancer Manag Res. 2020.

. 2020 Jun 8:12:4253-4260.

doi: 10.2147/CMAR.S254596. eCollection 2020.

Authors

Jie Li¹, Yan Gao¹, Wentao Yue¹

Affiliation

¹ Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, People's Republic of China.

PMID: 32606922
PMCID: PMC7292247
DOI: 10.2147/CMAR.S254596

Abstract

The Wnt signaling pathway extensively participates in diverse processes such as embryonic development, maintenance of homeostasis and tumor pathogenesis. Dickkopf-1 (DKK1), a Wnt inhibitor, plays a vital role for over the past decades regarding its role in the regulation of several types of cancers. However, studies have shown that DKK1 is expressed differently in cancer and plays a role as a cancer-promoting factor or a tumor suppressor, which is worthy of further exploration. We herein study whether DKK1 is highly expressed in all cancers and plays a crucial role in promoting cancer. Furthermore, we discussed as to which stages of cancer development it plays in. Finally, the present detection methods were introduced and indicated the clinical application of DKK1 in tumor development.

Keywords: Dickkopf-related protein1; Wnt signaling pathway; cancer diagnosis; cancer therapeutics; prognosis.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

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References

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1. Fedi P, Bafico A, Nieto Soria A, et al. Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling. J Biol Chem. 1999;274(27):19465–19472. doi:10.1074/jbc.274.27.19465 - DOI - PubMed
1. Glinka A, Wu W, Delius H, Monaghan AP, Blumenstock C, Niehrs C. Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature. 1998;391(6665):357–362. doi:10.1038/34848 - DOI - PubMed
1. Cappuccio I, Calderone A, Busceti CL, et al. Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is required for the development of ischemic neuronal death. J Neurosci. 2005;25(10):2647–2657. doi:10.1523/JNEUROSCI.5230-04.2005 - DOI - PMC - PubMed
1. Caricasole A, Copani A, Caraci F, et al. Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer’s brain. J Neurosci. 2004;24(26):6021–6027. doi:10.1523/JNEUROSCI.1381-04.2004 - DOI - PMC - PubMed

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[1] Niehrs C. Function and biological roles of the Dickkopf family of Wnt modulators. Oncogene. 2006;25(57):7469–7481. doi:10.1038/sj.onc.1210054 - DOI - PubMed

[2] Niehrs C. Function and biological roles of the Dickkopf family of Wnt modulators. Oncogene. 2006;25(57):7469–7481. doi:10.1038/sj.onc.1210054 - DOI - PubMed

[3] Fedi P, Bafico A, Nieto Soria A, et al. Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling. J Biol Chem. 1999;274(27):19465–19472. doi:10.1074/jbc.274.27.19465 - DOI - PubMed

[4] Fedi P, Bafico A, Nieto Soria A, et al. Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling. J Biol Chem. 1999;274(27):19465–19472. doi:10.1074/jbc.274.27.19465 - DOI - PubMed

[5] Glinka A, Wu W, Delius H, Monaghan AP, Blumenstock C, Niehrs C. Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature. 1998;391(6665):357–362. doi:10.1038/34848 - DOI - PubMed

[6] Glinka A, Wu W, Delius H, Monaghan AP, Blumenstock C, Niehrs C. Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature. 1998;391(6665):357–362. doi:10.1038/34848 - DOI - PubMed

[7] Cappuccio I, Calderone A, Busceti CL, et al. Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is required for the development of ischemic neuronal death. J Neurosci. 2005;25(10):2647–2657. doi:10.1523/JNEUROSCI.5230-04.2005 - DOI - PMC - PubMed

[8] Cappuccio I, Calderone A, Busceti CL, et al. Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is required for the development of ischemic neuronal death. J Neurosci. 2005;25(10):2647–2657. doi:10.1523/JNEUROSCI.5230-04.2005 - DOI - PMC - PubMed

[9] Caricasole A, Copani A, Caraci F, et al. Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer’s brain. J Neurosci. 2004;24(26):6021–6027. doi:10.1523/JNEUROSCI.1381-04.2004 - DOI - PMC - PubMed

[10] Caricasole A, Copani A, Caraci F, et al. Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer’s brain. J Neurosci. 2004;24(26):6021–6027. doi:10.1523/JNEUROSCI.1381-04.2004 - DOI - PMC - PubMed

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The Clinical Diagnostic and Prognostic Value of Dickkopf-1 in Cancer

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The Clinical Diagnostic and Prognostic Value of Dickkopf-1 in Cancer

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