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Randomized Controlled Trial
. 2020 Jul 1;29(4):311-317.
doi: 10.4037/ajcc2020498.

Relationship Between Intensive Care Unit Delirium Severity and 2-Year Mortality and Health Care Utilization

Patricia S Andrews  1 , Sophia Wang  2 , Anthony J Perkins  3 , Sujuan Gao  4 , Sikandar Khan  5 , Heidi Lindroth  6 , Malaz Boustani  7 , Babar Khan  8
Affiliations
Randomized Controlled Trial

Relationship Between Intensive Care Unit Delirium Severity and 2-Year Mortality and Health Care Utilization

Patricia S Andrews et al. Am J Crit Care. .

Abstract

Background: Critical care patients with delirium are at an increased risk of functional decline and mortality long term.

Objective: To determine the relationship between delirium severity in the intensive care unit and mortality and acute health care utilization within 2 years after hospital discharge.

Methods: A secondary data analysis of the Pharmacological Management of Delirium and Deprescribe randomized controlled trials. Patients were assessed twice daily for delirium or coma using the Richmond Agitation-Sedation Scale and the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). Delirium severity was measured using the CAM-ICU-7. Mean delirium severity (from time of randomization to discharge) was categorized as rapidly resolving, mild to moderate, or severe. Cox proportional hazards regression was used to model time to death, first emergency department visit, and rehospitalization. Analyses were adjusted for age, sex, race, Charlson Comorbidity Index, Acute Physiology and Chronic Health Evaluation II score, discharge location, diagnosis, and intensive care unit type.

Results: Of 434 patients, those with severe delirium had higher mortality risk than those with rapidly resolving delirium (hazard ratio 2.21; 95% CI, 1.35-3.61). Those with 5 or more days of delirium or coma had higher mortality risk than those with less than 5 days (hazard ratio 1.52; 95% CI, 1.07-2.17). Delirium severity and number of days of delirium or coma were not associated with time to emergency department visits and rehospitalizations.

Conclusion: Increased delirium severity and days of delirium or coma are associated with higher mortality risk 2 years after discharge.

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Figures

Figure 1.
Figure 1.
Delirium Severity and 2-Year Healthcare Outcomes
Figure 2.
Figure 2.
Delirium or Coma and Healthcare Outcomes
See this image and copyright information in PMC

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References

    1. Inouye SK, Westendorp RG, Saczynski JS. Delirium in elderly people. Lancet. 2014;383(9920):911–922. - PMC - PubMed
    1. Vasilevskis EE, Chandrasekhar R, Holtze CH, Graves J, Speroff T, Girard TD, Patel MB, Hughes CG, Cao A, Pandharipande PP, Ely EW. The cost of ICU delirium and coma in the intensive care unit patient. Med Care. 2018;56(10):890–897. - PMC - PubMed
    1. Hshieh TT, Inouye SK, Oh ES. Delirium in the elderly. Psychiatr Clin N Am. 2018;41(1):1–17. - PubMed
    1. Ely EW, Margolin R, Francis J, et al. Evaluation of delirium in critically ill patients: validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). Crit Care Med. 2001;29(7):1370–1379. - PubMed
    1. McNicoll L, Pisani MA, Zhang Y, Ely EW, Siegel MD, Inouye SK. Delirium in the intensive care unit: occurrence and clinical course in older patients. J Am Geriatr Soc. 2003;51(5):591–598 - PubMed

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