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. 2021 May;25(5):1124-1133.
doi: 10.1007/s11605-020-04710-7. Epub 2020 Jun 30.

Systemic Immune-Inflammation Index Predicts Overall Survival in Patients with Gastric Cancer: a Propensity Score-Matched Analysis

Noriyuki Hirahara  1 , Yoshitsugu Tajima  2 , Takeshi Matsubara  2 , Yusuke Fujii  2 , Shunsuke Kaji  2 , Yasunari Kawabata  2 , Ryoji Hyakudomi  2 , Tetsu Yamamoto  2 , Yuki Uchida  2 , Takahito Taniura  2
Affiliations

Systemic Immune-Inflammation Index Predicts Overall Survival in Patients with Gastric Cancer: a Propensity Score-Matched Analysis

Noriyuki Hirahara et al. J Gastrointest Surg. 2021 May.

Abstract

Background: The systemic immune-inflammation index (SII), integrated by peripheral lymphocyte, neutrophil, and platelet counts, is used as an objective biomarker that reflects the balance between host inflammatory and immune response status in cancer patients. Herein, we examined the prognostic significance of SII in gastric cancer patients.

Methods: We retrospectively reviewed data of 415 patients who underwent curative laparoscopic gastrectomy using propensity score-matched (PSM) analysis. The prognostic value of SII was compared between two groups based on SII values: low SII group (SII < 661.9) and high SII group (SII ≥ 661.9).

Results: In multivariate analysis, the American Society of Anesthesiologists physical status (ASA-PS) (p < 0.001), tumor differentiation (p = 0.019), pathological stage (p = 0.046), carcinoembryonic antigen (CEA) level (p < 0.001), SII (p = 0.006), and operative procedure (p = 0.009) were independent prognostic factors of overall survival (OS) in the overall PSM cohort. The log-rank test demonstrated that patients with a high SII had significantly worse OS than did those with low SII (p = 0.002). In age-stratified subgroups analysis (< 65/≥ 65 years), multivariate analysis revealed that ASA-PS (p < 0.001), tumor differentiation (p = 0.019), CEA level (p = 0.008), SII (p = 0.013), and operative procedure (p = 0.026) were independent prognostic factors of OS in the elderly group. Similarly, elderly patients with a high SII had significantly worse OS than did those with a low SII (p = 0.009). Meanwhile, SII was not an independent prognostic factor of OS, and no significant association was observed between SII and OS in non-elderly patients.

Conclusions: SII was an independent prognostic indicator in gastric cancer patients, especially in the elderly population.

Keywords: Gastric cancer; Overall survival; Systemic immune-inflammation index.

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References

    1. Farrow B, Sugiyama Y, Chen A, Uffort E, Nealon W, Mark Evers B. Inflammatory mechanisms contributing to pancreatic cancer development. Ann Surg 2004;239:763-769; discussion 769-771. - DOI
    1. Mimatsu K, Fukino N, Ogasawara Y, Saino Y, Oida T. Utility of inflammatory marker- and nutritional status-based prognostic factors for predicting the prognosis of stage IV gastric cancer patients undergoing non-curative surgery. Anticancer Res 2017;37:4215-4222. - PubMed
    1. Yun JK, McCormick TS, Villabona C, Judware RR, Espinosa MB, Lapetina EG. Inflammatory mediators are perpetuated in macrophages resistant to apoptosis induced by hypoxia. Proc Natl Acad Sci U S A 1997;94:13903-13908. - DOI
    1. Hirahara N, Matsubara T, Mizota Y, Ishibashi S, Tajima Y. Prognostic value of preoperative inflammatory response biomarkers in patients with esophageal cancer who undergo a curative thoracoscopic esophagectomy. BMC Surg 2016;16:66. doi: https://doi.org/10.1186/s12893-016-0179-5 . - DOI - PubMed - PMC
    1. Shimizu T, Taniguchi K, Asakuma M, Tomioka A, Inoue Y, Komeda K, Hirokawa F, Uchiyama K. Lymphocyte-to-monocyte ratio and prognostic nutritional index predict poor prognosis in patients on chemotherapy for unresectable pancreatic cancer. Anticancer Res 2019;39:2169-2176. doi: https://doi.org/10.21873/anticanres.13331 . - DOI - PubMed

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