Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jan 1:2020:baaa049.
doi: 10.1093/database/baaa049.

RNAWRE: a resource of writers, readers and erasers of RNA modifications

Fulei Nie  1 , Pengmian Feng  2 , Xiaoming Song  1 , Meng Wu  1 , Qiang Tang  3 , Wei Chen  1   3
Affiliations

RNAWRE: a resource of writers, readers and erasers of RNA modifications

Fulei Nie et al. Database (Oxford). .

Abstract

RNA modifications are involved in various kinds of cellular biological processes. Accumulated evidences have demonstrated that the functions of RNA modifications are determined by the effectors that can catalyze, recognize and remove RNA modifications. They are called 'writers', 'readers' and 'erasers'. The identification of RNA modification effectors will be helpful for understanding the regulatory mechanisms and biological functions of RNA modifications. In this work, we developed a database called RNAWRE that specially deposits RNA modification effectors. The current version of RNAWRE stored 2045 manually curated writers, readers and erasers for the six major kinds of RNA modifications, namely Cap, m1A, m6A, m5C, ψ and Poly A. The main modules of RNAWRE not only allow browsing and downloading the RNA modification effectors but also support the BLAST search of the potential RNA modification effectors in other species. We hope that RNAWRE will be helpful for the researches on RNA modifications. Database URL: http://rnawre.bio2db.com.

PubMed Disclaimer

Figures

Figure 1
Figure 1
The schematic flow for the construction of RNAWRE.
Figure 2
Figure 2
Statistical analysis of RNAWRE. The number effectors in each kind of modifications.
Figure 3
Figure 3
Web interface and usage of RNAWRE. (A) Home page. (B) Browse page by organism. (C) Browse page by modification type. (D) The detail page of RNA modification protein. (E) The search page of RNAWRE. (F) The statistical page.
See this image and copyright information in PMC

References

    1. Davis F.F. and Allen F.W. (1957) Ribonucleic acids from yeast which contain a fifth nucleotide. J. Biol. Chem., 227, 907–915. - PubMed
    1. Boccaletto P., Machnicka M.A., Purta E. et al. (2018) MODOMICS: a database of RNA modification pathways. 2017 update. Nucleic Acids Res., 46, D303–D307. - PMC - PubMed
    1. Wang X., Lu Z., Gomez A. et al. (2014) N6-methyladenosine-dependent regulation of messenger RNA stability. Nature, 505, 117–120. - PMC - PubMed
    1. Fustin J.M., Doi M., Yamaguchi Y. et al. (2013) RNA-methylation-dependent RNA processing controls the speed of the circadian clock. Cell, 155, 793–806. - PubMed
    1. Chen T., Hao Y.J., Zhang Y. et al. (2015) m(6)A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency. Cell Stem Cell, 16, 289–301. - PubMed

Publication types