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. 1988 Aug;56(8):2120-4.
doi: 10.1128/iai.56.8.2120-2124.1988.

Polyclonal B-cell stimulation by L3T4+ T cells in experimental leishmaniasis

M Lohoff  1 , C Matzner, M Röllinghoff
Affiliations

Polyclonal B-cell stimulation by L3T4+ T cells in experimental leishmaniasis

M Lohoff et al. Infect Immun. 1988 Aug.

Abstract

The well-established polyclonal B-cell stimulation in the lymphoid organs in mice infected with Leishmania major is thought to be dependent on T cells. Here we present clear experimental evidence that this is indeed the case by showing that BALB/c-derived, L3T4-positive L. major-specific T cells induce syngeneic B cells to polyclonal proliferation and immunoglobulin production.

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References

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