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. 2020 Aug 1;156(8):918-921.
doi: 10.1001/jamadermatol.2020.1984.

Use of Adjuvant Radiotherapy in the Treatment of High-risk Cutaneous Squamous Cell Carcinoma With Perineural Invasion

Affiliations

Use of Adjuvant Radiotherapy in the Treatment of High-risk Cutaneous Squamous Cell Carcinoma With Perineural Invasion

Mary L Stevenson et al. JAMA Dermatol. .

Abstract

This cohort study compares the use of adjuvant radiotherapy following surgery with surgery alone in patients treated for cutaneous squamous cell carcinoma with perineural invasion.

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Conflict of interest statement

Conflict of Interest Disclosures: This work was supported by a young investigator award in Dermatologic Surgery from the Dermatology Foundation (Dr Stevenson). No other disclosures were reported.

Figures

Figure.
Figure.. Disease-Free Survival
The estimated 5-year disease-free survival rate for patients treated with adjuvant radiotherapy was 100% (95% CI, 100%-100%) vs 68.8% (95% CI, 60.9%-76.7%) for those who did not receive adjuvant radiotherapy (P = .01).

References

    1. Thompson AK, Kelley BF, Prokop LJ, Murad MH, Baum CL. Risk factors for cutaneous squamous cell carcinoma recurrence, metastasis, and disease-specific death: a systematic review and meta-analysis. JAMA Dermatol. 2016;152(4):419-428. doi:10.1001/jamadermatol.2015.4994 - DOI - PMC - PubMed
    1. Miller J, Chang T, Schwartz D, Peters M, Baum C. Outcomes of adjuvant radiotherapy following negative surgical margins for cutaneous squamous cell carcinoma. Dermatol Surg. 2019;45(9):1111-1116. doi:10.1097/DSS.0000000000001827 - DOI - PubMed
    1. Jambusaria-Pahlajani A, Miller CJ, Quon H, Smith N, Klein RQ, Schmults CD. Surgical monotherapy versus surgery plus adjuvant radiotherapy in high-risk cutaneous squamous cell carcinoma: a systematic review of outcomes. Dermatol Surg. 2009;35(4):574-585. doi:10.1111/j.1524-4725.2009.01095.x - DOI - PubMed
    1. Veness MJ, Porceddu S, Palme CE, Morgan GJ. Cutaneous head and neck squamous cell carcinoma metastatic to parotid and cervical lymph nodes. Head Neck. 2007;29(7):621-631. doi:10.1002/hed.20576 - DOI - PubMed
    1. National Comprehensive Cancer Network Cutaneous squamous cell carcinoma. 2017.