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Randomized Controlled Trial
. 2020 Oct;55(10):2617-2623.
doi: 10.1002/ppul.24935. Epub 2020 Jul 10.

Nasal high-frequency percussive ventilation vs nasal continuous positive airway pressure in newborn infants respiratory distress: A cross over clinical trial

Laurent Renesme  1 , Eric Dumas de la Roque  1 , Christine Germain  2 , Agnès Chevrier  1 , Muriel Rebola  1 , Sophie Cramaregeas  1 , Antoine Benard  2 , Christophe Elleau  1 , Olivier Tandonnet  1
Affiliations
Randomized Controlled Trial

Nasal high-frequency percussive ventilation vs nasal continuous positive airway pressure in newborn infants respiratory distress: A cross over clinical trial

Laurent Renesme et al. Pediatr Pulmonol. 2020 Oct.

Abstract

Objective: To determine if nasal high-frequency percussive ventilation (nHFPV) to manage neonatal respiratory distress decreases the regional cerebral oxygen saturation (rScO2 ) compared to nasal continous positive airway pressure (nCPAP).

Study design: A prospective, randomized, monocentric, open-label, noninferiority crossover trial. Newborns of gestational age (GA) ≥ 33 weeks exhibiting persistent respiratory distress after 10 minutes of life were treated with nHFPV and nCPAP, in succession and in random order. The primary endpoint was the mean rScO2 , as revealed by near-infrared spectroscopy (NIRS).

Results: Forty-nine newborns were randomized; the mean GA and birth weight was 36.4 ± 1.9 weeks and 2718 ± 497 g. The mean rScO2 difference during the last 5 minutes of each ventilation mode (nHFPV minus nCPAP) was -0.7 ± 5.4% (95% confidence interval (CI) -2.25; 0.95%).

Conclusion: In our study on newborns of GA ≥33 weeks treated for respiratory distress, cerebral oxygenation via nHFPV was not inferior to nCPAP.

Keywords: cerebral oxygenation; nasal CPAP; nasal high-frequency percussive ventilation; neonatal respiratory distress; randomized controlled trial.

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References

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