Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Oct;26(10):2504-2506.
doi: 10.3201/eid2610.202648. Epub 2020 Jul 1.

Relative Bradycardia in Patients with Mild-to-Moderate Coronavirus Disease, Japan

Kazuhiko Ikeuchi, Makoto Saito, Shinya Yamamoto, Hiroyuki Nagai, Eisuke Adachi

Relative Bradycardia in Patients with Mild-to-Moderate Coronavirus Disease, Japan

Kazuhiko Ikeuchi et al. Emerg Infect Dis. 2020 Oct.

Abstract

Coronavirus disease is reported to affect the cardiovascular system. We showed that relative bradycardia was a common characteristic for 54 patients with PCR-confirmed mild-to-moderate coronavirus disease in Japan. This clinical sign could help clinicians to diagnose this disease.

Keywords: COVID-19; Japan; SARS-CoV-2; bradycardia; coronavirus disease; coronaviruses; mild-to-moderate coronavirus disease; relative bradycardia; respiratory infections; severe acute respiratory syndrome coronavirus 2; viruses.

PubMed Disclaimer

Figures

Figure
Figure
Predicted pulse rate over body temperature (red line) based on final random intercept model for relative bradycardia in patients with mild-to-moderate coronavirus disease, Japan. Black dashed lines indicate 95% CIs.
See this image and copyright information in PMC

Comment in

References

    1. Cunha BA. The diagnostic significance of relative bradycardia in infectious disease. Clin Microbiol Infect. 2000;6:633–4. 10.1046/j.1469-0691.2000.0194f.x - DOI - PubMed
    1. Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al.; China Medical Treatment Expert Group for Covid-19. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020;382:1708–20. 10.1056/NEJMoa2002032 - DOI - PMC - PubMed
    1. Lian J, Jin X, Hao S, Cai H, Zhang S, Zheng L, et al. Analysis of epidemiological and clinical features in older patients with corona virus disease 2019 (COVID-19) out of Wuhan. Clin Infect Dis. 2020;Mar 25:ciaa242. - PMC - PubMed
    1. Ye F, Hatahet M, Youniss MA, Toklu HZ, Mazza JJ, Yale S. The clinical significance of relative bradycardia. WMJ. 2018;117:73–8. - PubMed
    1. Ye F, Winchester D, Stalvey C, Jansen M, Lee A, Khuddus M, et al. Proposed mechanisms of relative bradycardia. Med Hypotheses. 2018;119:63–7. 10.1016/j.mehy.2018.07.014 - DOI - PubMed

MeSH terms

LinkOut - more resources