Stiffness Decouples Cellular Mechanosensation

Affiliations

¹ Departments of Mechanical and Aerospace Engineering, University of Central Florida, Orlando, Florida.
² Departments of Mechanical and Aerospace Engineering, University of Central Florida, Orlando, Florida; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida. Electronic address: rstewardjr@ucf.edu.

Comment

Vignesharavind Subramanianbalachandar et al. Biophys J. 2020.

. 2020 Jul 21;119(2):233.

doi: 10.1016/j.bpj.2020.06.008. Epub 2020 Jun 12.

¹ Departments of Mechanical and Aerospace Engineering, University of Central Florida, Orlando, Florida.
² Departments of Mechanical and Aerospace Engineering, University of Central Florida, Orlando, Florida; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida. Electronic address: rstewardjr@ucf.edu.

No abstract available

Comment on

Intercellular Adhesion Stiffness Moderates Cell Decoupling as a Function of Substrate Stiffness.
Vargas DA, Heck T, Smeets B, Ramon H, Parameswaran H, Van Oosterwyck H. Vargas DA, et al. Biophys J. 2020 Jul 21;119(2):243-257. doi: 10.1016/j.bpj.2020.05.036. Epub 2020 Jun 12. Biophys J. 2020. PMID: 32621867 Free PMC article.

1. Ladoux B., Mège R.-M. Mechanobiology of collective cell behaviours. Nat. Rev. Mol. Cell Biol. 2017;18:743–757. - PubMed
1. Vargas D.A., Heck T., Van Oosterwyck H. Intercellular adhesion stiffness moderates cell decoupling as a function of substrate stiffness. Biophys. J. 2020;119:243–257. - PMC - PubMed
1. Garcia S., Hannezo E., Gov N.S. Physics of active jamming during collective cellular motion in a monolayer. Proc. Natl. Acad. Sci. USA. 2015;112:15314–15319. - PMC - PubMed
1. Sadati M., Taheri Qazvini N., Fredberg J.J. Collective migration and cell jamming. Differentiation. 2013;86:121–125. - PMC - PubMed
1. Bi D., Lopez J.H., Lisa Manning M. A density-independent rigidity transition in biological tissues. Nat. Phys. 2015;11:1074–1079.