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. 2020 Oct;28(10):1826-1832.
doi: 10.1002/oby.22946. Epub 2020 Aug 27.

The Association of Obesity, Type 2 Diabetes, and Hypertension with Severe Coronavirus Disease 2019 on Admission Among Mexican Patients

Edgar Denova-Gutiérrez  1 , Hugo Lopez-Gatell  2 , Jose L Alomia-Zegarra  3 , Ruy López-Ridaura  4 , Christian A Zaragoza-Jimenez  3 , Dwigth D Dyer-Leal  5 , Ricardo Cortés-Alcala  5 , Tania Villa-Reyes  3 , Rosaura Gutiérrez-Vargas  3 , Kathia Rodríguez-González  3 , Carlos Escondrillas-Maya  3 , Tonatiuh Barrientos-Gutiérrez  6 , Juan A Rivera  1 , Simón Barquera  1
Affiliations

The Association of Obesity, Type 2 Diabetes, and Hypertension with Severe Coronavirus Disease 2019 on Admission Among Mexican Patients

Edgar Denova-Gutiérrez et al. Obesity (Silver Spring). 2020 Oct.

Abstract

Objective: This study's aim was to explore the association of obesity, type 2 diabetes, and hypertension with severe coronavirus disease 2019 (COVID-19) on admission.

Methods: In the present study, a total of 23,593 patient samples were evaluated by a laboratory from the Mexican Institute of Epidemiological Diagnosis and Reference. Of these, 18,443 were negative for COVID-19, 3,844 were positive for COVID-19, and 1,306 were positive for other respiratory viruses. Severe types of respiratory disease were defined by the presence of pneumonia and other organ failure that requires intensive care. Multivariable logistic regression models were used to explore factors associated with severe COVID-19 on admission.

Results: Patients who tested positive for COVID-19 had a higher proportion of obesity (17.4%), diabetes (14.5%), and hypertension (18.9%) compared with those without a confirmed diagnosis. Compared with patients without obesity, those with obesity showed a 1.43-fold higher odds of developing severe COVID-19 on admission, whereas subjects with diabetes and hypertension showed a 1.87-fold and 1.77-fold higher odds of developing severe COVID-19 on admission, respectively.

Conclusions: Obesity, diabetes, and hypertension were significantly associated with severe COVID-19 on admission and the association of obesity was stronger in patients < 50 years of age.

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Conflict of interest statement

The authors declared no conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of the Mexican National Epidemiological Surveillance System for Viral Respiratory Disease.
Figure 2
Figure 2
Joint association of obesity and age (≤50 and >50 years) with severe coronavirus disease 2019 (COVID‐19) on admission in the Mexican population. The reference group for comparisons was composed of subjects without obesity who were 50 years of age or younger. Odds ratios were adjusted for age (years), sex, smoking status, history of chronic diseases (hypertension, diabetes, cardiovascular disease, chronic kidney disease, immunosuppression, place of care, unit of the system of selected health units that monitor respiratory diseases (USMER), date of symptom onset, and drug treatment.
See this image and copyright information in PMC

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