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Editorial
. 2020 Jul;13(7):e007208.
doi: 10.1161/CIRCHEARTFAILURE.120.007208. Epub 2020 Jul 2.

Natriuretic Peptides, Inflammation, and Sounding the Alarm

Vijay Ramakrishnan  1   2 , John C Burnett Jr  1   3
Affiliations
Editorial

Natriuretic Peptides, Inflammation, and Sounding the Alarm

Vijay Ramakrishnan et al. Circ Heart Fail. 2020 Jul.
No abstract available

Keywords: cytokines; editorials; endothelial cells; inflammation; natriuresis; peptides.

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Conflict of interest statement

Disclosures: None.

Figures

Figure:
Figure:
A - Under normal physiological conditions, inflammatory homeostasis is maintained by the the balance of pro-inflammatory and anti-inflammatory cytokines. In response to acute inflammatory stimuli or in chronic inflammatory conditions, pro-inflammatory cytokines such as IL-6 and TNF-α are up-regulated. In the absence of anti-inflammatory factors, a pro-inflammatory state is activated resulting contributing to disease progression. B - The findings by Fish-Trotter and Ferguson demonstrate that in response to different inflammatory stimuli, there is a strong association between pro-inflammatory cytokines and circulating levels of forms of the natriuretic peptides released by the heart and may serve as biomarkers for underlying inflammation. Given that the natriuretic peptides have been shown to have protective immune modulatory functions, we propose that increased natriuretic peptide production is an intrinsic protective mechanism to maintain inflammatory homeostasis.
See this image and copyright information in PMC

Comment on

  • Inflammation and Circulating Natriuretic Peptide Levels.
    Fish-Trotter H, Ferguson JF, Patel N, Arora P, Allen NB, Bachmann KN, Daniels LB, Reilly MP, Lima JAC, Wang TJ, Gupta DK. Fish-Trotter H, et al. Circ Heart Fail. 2020 Jul;13(7):e006570. doi: 10.1161/CIRCHEARTFAILURE.119.006570. Epub 2020 Jun 8. Circ Heart Fail. 2020. PMID: 32507024 Free PMC article.

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