Utility of Human-Derived Models for Glioblastoma
- PMID: 32611734
- PMCID: PMC8283797
- DOI: 10.1158/2159-8290.CD-20-0493
Utility of Human-Derived Models for Glioblastoma
Abstract
In this issue, Pine and colleagues compared single-cell RNA-sequencing data across four distinct types of glioblastoma stem cell-derived tumor models, reinforcing the importance of a three-dimensional microenvironment for accurate recapitulation of cellular states.See related article by Pine et al., p. 964.
©2020 American Association for Cancer Research.
Conflict of interest statement
Disclosure of Potential Conflicts of Interest
No potential conflicts of interest were disclosed.
Figures
Comment on
-
Tumor Microenvironment Is Critical for the Maintenance of Cellular States Found in Primary Glioblastomas.Cancer Discov. 2020 Jul;10(7):964-979. doi: 10.1158/2159-8290.CD-20-0057. Epub 2020 Apr 6. Cancer Discov. 2020. PMID: 32253265 Free PMC article.
References
-
- Lee J, Kotliarova S, Kotliarov Y, Li A, Su Q, Donin NM, et al. Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell 2006;9:391–403. - PubMed
-
- Lancaster MA, Knoblich JA. Organogenesis in a dish: Modeling development and disease using organoid technologies. Science 2014;345: 1247125. - PubMed
