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. 1988:27 Suppl 2:58-60.
doi: 10.1093/rheumatology/xxvii.suppl_2.58.

Rabbit antisera to enterobacteriaceae isolated from HLA-B27 positive patients with ankylosing spondylitis (AS) are lytic for the mononuclear cells of AS patients

C J Beukelman, A van Leeuwen, P C Aerts, E van Kregten, S van Bree, J J van Rood, J M Willers, H van Dijk

Rabbit antisera to enterobacteriaceae isolated from HLA-B27 positive patients with ankylosing spondylitis (AS) are lytic for the mononuclear cells of AS patients

C J Beukelman et al. Br J Rheumatol. 1988.

Abstract

Vaccines prepared from Gram-negative bacteria isolated from the stools of HLA-B27 positive AS patients were used to immunize rabbits. Three of the sera obtained were lytic in vitro for the mononuclear cells of HLA-B27 positive AS patients. One of these sera discriminated between AS patients and healthy HLA-B27 positive individuals. Cytolysis was determined in an automated, non-radioactive assay based on the release of carboxyfluorescein diacetate and the incorporation of propidium iodide.

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