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. 2021 Feb;59(2):112-122.
doi: 10.1038/s41393-020-0508-5. Epub 2020 Jul 1.

Cannabinoids and an anti-inflammatory diet for the treatment of neuropathic pain after spinal cord injury (The CATNP Study): study protocol for a randomized controlled trial

David J Allison  1   2   3   4 , Alexandria Roa Agudelo  5   6   7 , Brian C F Chan  8   9 , David S Ditor  10 , Eldon Loh  5   6   7
Affiliations

Cannabinoids and an anti-inflammatory diet for the treatment of neuropathic pain after spinal cord injury (The CATNP Study): study protocol for a randomized controlled trial

David J Allison et al. Spinal Cord. 2021 Feb.

Abstract

Study design: Multicenter, randomized, double-blind, placebo controlled, clinical trial.

Objective: The objective of this paper is to evaluate the effectiveness of cannabinoids and an anti-inflammatory diet, alone and in combination, for the management of neuropathic pain (NP) after spinal cord injury (SCI).

Setting: Two Canadian SCI rehabilitation centers.

Methods: A sample of 144 individuals with SCI will receive either an anti-inflammatory diet, cannabinoids or a placebo for 6 weeks. Following this, a combined effect of these treatments will be evaluated for a further 6 weeks. The primary outcome measure will be the change in NP as assessed by the numeric rating scale (NRS). Secondary outcomes will include changes in inflammation, mood, sleep, spasticity, cost-effectiveness, and function.

Conclusion: This study will assess the efficacy of an anti-inflammatory diet and cannabinoids (individually and in combination) for the treatment of NP following SCI. Results may reveal a cost-effective, side-effect free intervention strategy which could be utilized for the long-term management of NP following SCI.

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References

    1. Siddall PJ, Loeser JD. Pain following spinal cord injury. Spinal Cord. 2001;39:63–73. https://doi.org/10.1038/sj.sc.3101116. - DOI - PubMed
    1. Henwood P, Ellis JA. Chronic neuropathic pain in spinal cord injury: the patient’s perspective. Pain Res Manag. 2004;9:39–45. https://doi.org/10.1155/2004/863062. - DOI - PubMed
    1. Ashton JC, Milligan ED. Cannabinoids for the treatment of neuropathic pain: clinical evidence. Curr Opin Investig Drugs. 2008;9:65–75. - PubMed
    1. Cardenas DD, Jensen MP. Treatments for Chronic Pain in Persons With Spinal Cord Injury: A Survey Study 2005:109–17.
    1. Corroon JM, Mischley LK, Sexton M. Cannabis as a substitute for prescription drugs—a cross-sectional study. J Pain Res. 2017;10:989–98. https://doi.org/10.2147/JPR.S134330. - DOI - PubMed - PMC

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