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Comparative Study
. 2020 Jun 24:16:249-256.
doi: 10.2147/VHRM.S251927. eCollection 2020.

Association Metabolic Obesity Phenotypes with Cardiometabolic Index, Atherogenic Index of Plasma and Novel Anthropometric Indices: A Link of FTO-rs9939609 Polymorphism

Farhad Abolnezhadian  1 , Seyed Ahmad Hosseini  2   3 , Meysam Alipour  3 , Mehrnoosh Zakerkish  4 , Bahman Cheraghian  5 , Pegah Ghandil  6 , Makan Cheraghpour  3
Affiliations
Comparative Study

Association Metabolic Obesity Phenotypes with Cardiometabolic Index, Atherogenic Index of Plasma and Novel Anthropometric Indices: A Link of FTO-rs9939609 Polymorphism

Farhad Abolnezhadian et al. Vasc Health Risk Manag. .

Abstract

Background: The role of metabolic states in cardiovascular risks among individuals with varying degrees of obesity is unknown. The study aimed to compare cardiometabolic index (CMI), atherogenic index of plasma (AIP), lipid accumulation product (LAP) and novel anthropometric indices in metabolic and non-metabolically obese individual with regard to the role of FTO gene in Iranian adults.

Methods: In total, 165 individuals were recruited into this cross-sectional study. Individuals grouped into four groups: metabolic healthy normal-weight (MHNW) individuals, metabolically unhealthy normal-weight (MUNW) individuals, metabolically healthy obese (MHO) individuals and metabolic unhealthy obese (MUO) individuals. The dietary intake was evaluated by food frequency questionnaire (FFQ). The cardiovascular indices (CMI, AIP and LAP) were calculated. A variety of anthropometric indices were calculated, including body adiposity Index (BAI), weight-adjusted-waist index (WWI), A body shape index (ABSI) and waist-height ratio (WHR). The genotypes of FTO-rs9939609 subjects were detected by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).

Results: The individuals with metabolically unhealthy phenotypes (MUO, MUNW) have higher levels of triglyceride and cardiovascular indices (AIP, LAP and CMI) than the individuals with metabolic healthy phenotypes (MHO, MHNW). With a similar degree of obesity, the anthropometric indices (BAI, WWI and WHR) levels were higher in metabolic unhealthy groups than metabolically healthy groups. The highest frequency of obesity-risk allele AA of FTO gene was observed in MUO, MHO, MUNW and MHNW, respectively.

Conclusion: Normal-weight individuals with metabolic unhealthy status are at higher risk for cardiovascular diseases than obese individuals with metabolically healthy status. The genotype frequencies of obesity-risk allele AA of FTO gene were higher in obesity phenotypes than metabolic phenotypes.

Keywords: FTO; atherogenic index; cardiovascular; obesity.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Compare body adiposity index between metabolical obesity phenotype. The asterisk (*) indicates a significant difference between two groups.
Figure 2
Figure 2
Compare a body shape index between metabolical obesity phenotype. The asterisk (*) indicates a significant difference between two groups.
Figure 3
Figure 3
Compare weight-adjusted-weight index between metabolical obesity phenotype. The asterisk (*) indicates a significant difference between two groups.
Figure 4
Figure 4
Compare atherogenetic index of placema between metabolical obesity phenotype. The asterisk (*) indicates a significant difference between two groups.
Figure 5
Figure 5
Compare lipid accumulation product between metabolical obesity phenotype. The asterisk (*) indicates a significant difference between two groups.
Figure 6
Figure 6
Compare cardiometabolic index between metabolical obesity phenotype. The asterisk (*) indicates a significant difference between two groups.
See this image and copyright information in PMC

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