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. 2020 Aug;29(8):699-702.
doi: 10.1111/exd.14138. Epub 2020 Jul 20.

Can moderate-intensity aerobic exercise ameliorate atopic dermatitis?

Wang Kuk Son  1   2 , Wonsuck Yoon  1 , Seunghyun Kim  1 , Jung Hye Byeon  3 , Jue Seong Lee  3 , Dasarang Kim  1 , Lim Jaehoon  1 , Yangseok Chae  4 , Sung Jin Yoon  2 , Young Yoo  1   3
Affiliations

Can moderate-intensity aerobic exercise ameliorate atopic dermatitis?

Wang Kuk Son et al. Exp Dermatol. 2020 Aug.

Abstract

It has been shown that aerobic exercise improves atopic dermatitis (AD), although the mechanism is not clear. Here, we propose a hypothesis that moderate-intensity aerobic exercise improves AD in a mouse model through modulating allergic inflammation. The DNCB-treated mouse model for eczema was divided into 3 groups: (a) not subjected to aerobic exercise, (b) subjected to continuous aerobic exercise and (c) subjected to accumulated aerobic exercise. After given exercise using a treadmill device either 30 min/d or 10 min × 3/day at a speed of 16 m/min, for 9 days, respectively, dermatitis symptom score, thickness of epidermis/dermis and eosinophil infiltration were decreased in the 2 exercise groups compared to the sedentary living group. The serum levels of IgE, MCP-1 and MDC showed a significant decrease both in the continuous or accumulated exercise groups. Moderate-intensity aerobic exercise ameliorates dermatitis symptoms through immune modulation in the DNCB-treated mouse model for eczema.

Keywords: aerobic exercise; atopic dermatitis; immunoglobulin E; macrophage-derived chemokine; monocyte chemotactic protein-1.

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