Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2020 Oct;26(10):2522-2533.
doi: 10.3201/eid2610.202127. Epub 2020 Jul 2.

Pulmonary Embolism and Increased Levels of D-Dimer in Patients with Coronavirus Disease

Comment

Pulmonary Embolism and Increased Levels of D-Dimer in Patients with Coronavirus Disease

Kok Hoe Chan et al. Emerg Infect Dis. 2020 Oct.
No abstract available

Keywords: COVID-19; Factor XIII deficiency; SARS-CoV-2; coronavirus disease; cytokine storm; interleukin-6 receptor; plasminogen activator; proteolytic enzymes; respiratory infections; severe acute respiratory syndrome coronavirus 2; tocilizumab; transient hypercoagulable state; venous thromboembolism; viruses.

PubMed Disclaimer

Comment on

References

    1. Griffin DO, Jensen A, Khan M, Chin J, Chin K, Saad J, et al. Pulmonary embolism and increased levels of d-dimer in patients with coronavirus disease. Emerg Infect Dis. 2020;26. 10.3201/eid2608.201477 - DOI - PMC - PubMed
    1. Zhang C, Wu Z, Li JW, Zhao H, Wang GQ. The cytokine release syndrome (CRS) of severe COVID-19 and Interleukin-6 receptor (IL-6R) antagonist tocilizumab may be the key to reduce the mortality. Int J Antimicrob Agents. 2020;55:105954. 10.1016/j.ijantimicag.2020.105954 - DOI - PMC - PubMed
    1. Zhang Y, Zhang Z, Wei R, Miao X, Sun S, Liang G, et al. IL (interleukin)-6 contributes to deep vein thrombosis and is negatively regulated by miR-338-5p. Arterioscler Thromb Vasc Biol. 2020;40:323–34. 10.1161/ATVBAHA.119.313137 - DOI - PMC - PubMed
    1. Nosaka M, Ishida Y, Kimura A, Kuninaka Y, Taruya A, Ozaki M, et al. Crucial involvement of IL-6 in thrombus resolution in mice via macrophage recruitment and the induction of proteolytic enzymes. Front Immunol. 2020;10:3150. 10.3389/fimmu.2019.03150 - DOI - PMC - PubMed
    1. Jewell P, Ansorge O, Kuker W, Irani SR, Zamboni G. Tocilizumab-associated multifocal cerebral thrombotic microangiopathy. Neurol Clin Pract. 2016;6:e24–6. 10.1212/CPJ.0000000000000220 - DOI - PMC - PubMed

Substances