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Review
. 2020 Jun 30;15(6):236-238.
doi: 10.1002/cld.907. eCollection 2020 Jun.

Cholangitis Lenta: What Hepatologists Need to Know

Adam L Booth  1 , Shehzad N Merwat  2 , Sheharyar K Merwat  2 , Heather L Stevenson  1
Affiliations
Review

Cholangitis Lenta: What Hepatologists Need to Know

Adam L Booth et al. Clin Liver Dis (Hoboken). .

Abstract

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Figures

Figure 1
Figure 1
Hallmark features of cholangitis lenta. Periportal proliferation of dilated bile ductules (black arrows) containing inspissated bile (white arrow).
Figure 2
Figure 2
Typical pattern of portal inflammation. A portal tract showing minimal‐to‐mild lymphoplasmacytic inflammation (black arrow) with occasional neutrophils (white arrow) and eosinophils. Portal edema is an uncommon finding and is minimal to mild when present.
Figure 3
Figure 3
Lobular and hepatocyte injury. Hepatocyte swelling (black arrows) and feathery degeneration from cholestasis (arrowheads) are common histological findings more frequently observed in zone 3 and may be associated with centrilobular necrosis (white arrow).
Figure 4
Figure 4
Liver biopsy at low magnification demonstrating the uniformity of the process. Note the marked periportal dilated bile ductules (black arrows) with inspissated bile and zone 1 canalicular cholestasis (white arrows). The zone 3 centrilobular region is marked by hemorrhage and ongoing hepatocyte injury (arrowheads).
See this image and copyright information in PMC

References

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