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Comment
. 2020 Aug;15(5):871-874.
doi: 10.1007/s11739-020-02423-y. Epub 2020 Jul 2.

A COVID-19 patient with seven consecutive false-negative rRT-PCR results from sputum specimens

Cong-Ying Song  1   2 , Da-Gan Yang  3 , Yuan-Qiang Lu  4   5
Affiliations
Comment

A COVID-19 patient with seven consecutive false-negative rRT-PCR results from sputum specimens

Cong-Ying Song et al. Intern Emerg Med. 2020 Aug.
No abstract available

Keywords: COVID-19; False-negative; SARS-CoV-2; rRT-PCR.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Imaging features of chest CT. a CT on day 4 (with initial negative rRT-PCR SARS-CoV-2 results) showed patchy dense shadows with mixed ground-glass opacity in the left lower lung. b CT on day 8 (with negative rRT-PCR result) showed patchy and nodular dense shadows in both lower lungs. The scope of pulmonary lesions is enlarged. c CT on day 11 (with initial positive rRT-PCR result) showed multiple patchy and strip-like dense shadows in both lungs. The lesions have progressed. d CT on day 14 (with positive rRT-PCR result) showed multiple patchy and high dense shadows in both lungs, mainly in the peripheral zone of the lower lobes. The lesions progressed significantly. CT computed tomography, rRT-PCR real-time reverse transcription-polymerase chain reaction, SARS-CoV-2 severe acute respiratory syndrome coronavirus 2
Fig. 2
Fig. 2
Disease development and treatment application. The development process of the disease is shown starting from the illness onset. The patient was admitted to our hospital 3 days after illness onset. rRT-PCR results were consistently negative until 11 days after illness onset (day 8 after admission). The lesions shown in CT progressed before the first positive rRT-PCR result. The virus duration in the respiratory samples was 4 days, during which the pulmonary lesions progressed. After that, patient symptoms were relieved, and the pulmonary lesions were absorbed. CT computed tomography, rRT-PCR real-time reverse transcription-polymerase chain reaction
Fig. 3
Fig. 3
Imaging features of lung ultrasound. a Lung ultrasound of the left lower lung (day 14) showed confluent B lines, which can be found in interstitial pneumonia. This area showed patchy and strip-like dense shadows on CT. b Lung ultrasound of the right lower lung (day 14) showed air bronchograms and shred signs, which are features of lung consolidation. These features were similar to those of CT. CT computed tomography
See this image and copyright information in PMC

Comment on

References

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