Letter to the Editor: Does c-Jun N-Terminal Kinase Regulate Acetaminophen Hepatotoxicity by Modulating Nuclear Factor Erythroid 2-Related Factor 2-Dependent Genes or Mitochondrial Oxidant Stress?
- PMID: 32617995
- DOI: 10.1002/hep.31442
Letter to the Editor: Does c-Jun N-Terminal Kinase Regulate Acetaminophen Hepatotoxicity by Modulating Nuclear Factor Erythroid 2-Related Factor 2-Dependent Genes or Mitochondrial Oxidant Stress?
Comment in
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REPLY.Hepatology. 2021 Jan;73(1):468-469. doi: 10.1002/hep.31441. Epub 2020 Dec 7. Hepatology. 2021. PMID: 32614089 No abstract available.
Comment on
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c-Jun NH2 -Terminal Protein Kinase Phosphorylates the Nrf2-ECH Homology 6 Domain of Nuclear Factor Erythroid 2-Related Factor 2 and Downregulates Cytoprotective Genes in Acetaminophen-Induced Liver Injury in Mice.Hepatology. 2020 May;71(5):1787-1801. doi: 10.1002/hep.31116. Hepatology. 2020. PMID: 31945188 Free PMC article.
References
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- Chen Y, Liu K, Zhang J, Hai Y, Wang P, Wang H, et al. c-Jun NH2-terminal protein kinase phosphorylates the Nrf2-ECH homology 6 domain of nuclear factor erythroid 2-related factor 2 and downregulates cytoprotective genes in acetaminophen-induced liver injury in mice. Hepatology 2020;71:1787-1801.
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- Ramachandran A, Jaeschke H. Acetaminophen hepatotoxicity. Semin Liver Dis 2019;39:221-234.
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- Akakpo JY, Ramachandran A, Duan L, Schaich MA, Jaeschke MW, Freudenthal BD, et al. Delayed treatment with 4-methylpyrazole protects against acetaminophen hepatotoxicity in mice by inhibition of c-jun N-terminal kinase. Toxicol Sci 2019;170:57-68.
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- Du K, Farhood A, Jaeschke H. Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity. Arch Toxicol 2017;91:761-773.
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- Duan L, Ramachandran A, Akakpo JY, Woolbright BL, Zhang Y, Jaeschke H. Mice deficient in pyruvate dehydrogenase kinase 4 are protected against acetaminophen-induced hepatotoxicity. Toxicol Appl Pharmacol 2020;387:114849.
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