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Comment
. 2021 Jan;73(1):467-468.
doi: 10.1002/hep.31442. Epub 2020 Dec 7.

Letter to the Editor: Does c-Jun N-Terminal Kinase Regulate Acetaminophen Hepatotoxicity by Modulating Nuclear Factor Erythroid 2-Related Factor 2-Dependent Genes or Mitochondrial Oxidant Stress?

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Comment

Letter to the Editor: Does c-Jun N-Terminal Kinase Regulate Acetaminophen Hepatotoxicity by Modulating Nuclear Factor Erythroid 2-Related Factor 2-Dependent Genes or Mitochondrial Oxidant Stress?

Hartmut Jaeschke et al. Hepatology. 2021 Jan.
No abstract available

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Comment in

  • REPLY.
    Tang X, Wang XJ. Tang X, et al. Hepatology. 2021 Jan;73(1):468-469. doi: 10.1002/hep.31441. Epub 2020 Dec 7. Hepatology. 2021. PMID: 32614089 No abstract available.

Comment on

References

    1. Chen Y, Liu K, Zhang J, Hai Y, Wang P, Wang H, et al. c-Jun NH2-terminal protein kinase phosphorylates the Nrf2-ECH homology 6 domain of nuclear factor erythroid 2-related factor 2 and downregulates cytoprotective genes in acetaminophen-induced liver injury in mice. Hepatology 2020;71:1787-1801.
    1. Ramachandran A, Jaeschke H. Acetaminophen hepatotoxicity. Semin Liver Dis 2019;39:221-234.
    1. Akakpo JY, Ramachandran A, Duan L, Schaich MA, Jaeschke MW, Freudenthal BD, et al. Delayed treatment with 4-methylpyrazole protects against acetaminophen hepatotoxicity in mice by inhibition of c-jun N-terminal kinase. Toxicol Sci 2019;170:57-68.
    1. Du K, Farhood A, Jaeschke H. Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity. Arch Toxicol 2017;91:761-773.
    1. Duan L, Ramachandran A, Akakpo JY, Woolbright BL, Zhang Y, Jaeschke H. Mice deficient in pyruvate dehydrogenase kinase 4 are protected against acetaminophen-induced hepatotoxicity. Toxicol Appl Pharmacol 2020;387:114849.