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Review
. 2021 Jan;156(2):162-181.
doi: 10.1111/jnc.15112. Epub 2020 Aug 6.

Diagnostic and therapeutic potential of exosomes in Alzheimer's disease

Tânia Soares Martins  1 , Dário Trindade  1 , Margarida Vaz  1 , Inês Campelo  2 , Martim Almeida  2 , Guilherme Trigo  2 , Odete A B da Cruz E Silva  1   3 , Ana Gabriela Henriques  1
Affiliations
Review

Diagnostic and therapeutic potential of exosomes in Alzheimer's disease

Tânia Soares Martins et al. J Neurochem. 2021 Jan.

Abstract

Exosomes are small extracellular vesicles released by almost all cell types in physiological and pathological conditions. The exosomal potential to unravel disease mechanisms, or to be used as a source of biomarkers, is being explored, in particularly in the field of neurodegenerative diseases. Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the world and exosomes appear to have a relevant role in disease pathogenesis. This review summarizes the current knowledge on exosome contributions to AD as well as their use as disease biomarker resources or therapeutic targets. The most recent findings with respect to both protein and miRNA biomarker candidates for AD, herein described, highlight the state of the art in this field and encourage the use of exosomes derived from biofluids in clinical practice in the near future.

Keywords: Alzheimer's Disease; biomarker; diagnosis; exosome; therapeutics.

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References

REFERENCES

    1. Agliardi, C., Guerini, F. R., Zanzottera, M., Bianchi, A., Nemni, R., & Clerici, M. (2019). SNAP-25 in serum is carried by exosomes of neuronal origin and is a potential biomarker of Alzheimer’s disease. Molecular Neurobiology, 56, 5792-5798. https://doi.org/10.1007/s12035-019-1501-x.
    1. Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. A. (2011). Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nature Biotechnology, 29, 341-345. https://doi.org/10.1038/nbt.1807.
    1. An, K., Klyubin, I., Kim, Y., Jung, J. H., Mably, A. J., O’Dowd, S. T., … Kim, J.-H. (2013). Exosomes neutralize synaptic-plasticity-disrupting activity of Aβ assemblies in vivo. Molecular Brain, 6, 47.https://doi.org/10.1186/1756-6606-6-47.
    1. Armstrong, D., & Wildman, D. E. (2018). Extracellular vesicles and the promise of continuous liquid biopsies. Journal of Pathology and Translational Medicine, 52, 1-8. https://doi.org/10.4132/jptm.2017.05.21.
    1. Asai, H., Ikezu, S., Tsunoda, S., Medalla, M., Luebke, J., Haydar, T., … Ikezu, T. (2015). Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nature Neuroscience, 18, 1584-1593. https://doi.org/10.1038/nn.4132.

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