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Review
. 2020 Sep;36(5):452-455.
doi: 10.1097/MOG.0000000000000660.

Expanding indications for pancreatic islet cell transplantation

Affiliations
Review

Expanding indications for pancreatic islet cell transplantation

Carly B Miles et al. Curr Opin Gastroenterol. 2020 Sep.

Abstract

Purpose of review: We aimed to summarize the current state of performing pancreatic islet autotransplantation (IAT) for indications other than total pancreatectomy for chronic pancreatitis.

Recent findings: The current article will review expanded indications for IAT including partial pancreatectomy for benign inflammatory disease, trauma, pancreatic islet cell tumor and pancreatic adenocarcinoma. In the context of more access for IAT as more centers are offering this clinical service, these expanded indications will continue to push the limits of our ability to make IAT accessible.

Summary: Pancreatic islet cell transplantation is increasingly being used for new indications related to benign disease and malignancy. We expect continued expansion of its use as IAT becomes more accessible.

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References

    1. Najarian JS, Sutherland DE, Matas AJ, et al. Human islet transplantation: a preliminary report. Transplant Proc 1977; 9:233–236.
    1. Gardner TB, Adler DA, Forsmark CE, et al. ACG clinical guideline: chronic pancreatitis. Am J Gastroenterol 2020; 115:322–339.
    1. McEachron KR, Bellin MD. Total pancreatectomy and islet autotransplantion for chronic and recurrent acute pancreatitis. Curr Opin Gastroenterol 2018; 34:367–373.
    1. Balzano G, Maffi P, Nano R, et al. Diabetes-free survival after extended distal pancreatectomy and islet auto transplantation for benign or borderline/malignant lesions of the pancreas. Am J Transplant 2019; 19:920–928.
    1. Siegel M, Barlowe TW, Smith KD, et al. Islet autotransplantation improves glycemic control in patients undergoing elective distal pancreatectomy for benign inflammatory disease. Clin Transplant 2020; e13891(Dartmouth internal data).