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. 2020 Oct;9(10):1129-1136.
doi: 10.1002/sctm.20-0055. Epub 2020 Jul 3.

CIRM tools and technologies: Breaking bottlenecks to the development of stem cell therapies

Lila R Collins  1 , Kelly A Shepard  1
Affiliations

CIRM tools and technologies: Breaking bottlenecks to the development of stem cell therapies

Lila R Collins et al. Stem Cells Transl Med. 2020 Oct.

Abstract

The California Institute for Regenerative Medicine (CIRM) has a mission to accelerate stem cell treatments to patients with unmet medical needs. This perspective describes successful examples of work funded by CIRM's New Cell Lines and Tools and Technologies Initiatives, which were developed to address bottlenecks to stem cell research and translation. The tools developed through these programs evolved from more discovery-oriented technologies, such as disease models, differentiation processes, and assays, to more translation focused tools, including scalable good manufacturing processes, animal models, and tools for clinical cell delivery. These tools are available to the research community and many are facilitating translation of regenerative therapeutics today.

Keywords: animal Models; cellular therapy; clinical translation; differentiation; direct cell conversion; induced pluripotent stem cells (iPSCs); stem cell transplantation.

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Conflict of interest statement

The authors declared no potential conflicts of interest.

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