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Comment
. 2020 Jul 2;27(1):3-5.
doi: 10.1016/j.stem.2020.06.009.

Rubbing Out Leukemia Stem Cells by Erasing the Eraser

Yuanming Cheng  1 , Hanzhi Luo  1 , Michael G Kharas  2
Affiliations
Comment

Rubbing Out Leukemia Stem Cells by Erasing the Eraser

Yuanming Cheng et al. Cell Stem Cell. .

Abstract

In this issue of Cell Stem Cell, Shen et al. (2020) and Wang et al. (2020) independently identify the essential function of m6A demethylase ALKBH5 in maintaining myeloid leukemia stem cells. These studies expand the regulators of the epitranscriptome that are required for acute myeloid leukemia (AML) development.

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Conflict of interest statement

Declaration of Interests M.G.K. is a consultant for Accent Therapeutics and M.G.K.’s laboratory receives some financial support from 28-7. These disclosures are not directly related to these studies.

Figures

Figure 1.
Figure 1.. ALKBH5 Maintains Leukemia Stem Cells in AML Development
Demethylation of H3K9me3 by KDM4C increases the chromatin accessibility at ALKBH5 locus resulting in high expression of ALKBH5 in leukemia stem cells. ALKBH5 controls leukemia stem cell self-renewal by removing m6A marks from transcripts to promote expression of its targets including TACC3, AXL, etc. in AML.
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References

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