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Observational Study
. 2020 Nov;81(5):816-846.
doi: 10.1016/j.jinf.2020.06.073. Epub 2020 Jun 30.

Clinical recurrences of COVID-19 symptoms after recovery: Viral relapse, reinfection or inflammatory rebound?

Marie Gousseff  1 , Pauline Penot  2 , Laure Gallay  3 , Dominique Batisse  4 , Nicolas Benech  5 , Kevin Bouiller  6 , Rocco Collarino  7 , Anne Conrad  8 , Dorsaf Slama  9 , Cédric Joseph  10 , Adrien Lemaignen  11 , François-Xavier Lescure  12 , Bruno Levy  13 , Matthieu Mahevas  14 , Bruno Pozzetto  15 , Nicolas Vignier  16 , Benjamin Wyplosz  17 , Dominique Salmon  18 , Francois Goehringer  19 , Elisabeth Botelho-Nevers  20 ; in behalf of the COCOREC study group
Affiliations
Observational Study

Clinical recurrences of COVID-19 symptoms after recovery: Viral relapse, reinfection or inflammatory rebound?

Marie Gousseff et al. J Infect. 2020 Nov.

Abstract

For the first 3 months of COVID-19 pandemic, COVID-19 was expected to be an immunizing non-relapsing disease. We report a national case series of 11 virologically-confirmed COVID-19 patients having experienced a second clinically- and virologically-confirmed acute COVID-19 episode. According to the clinical history, we discuss either re-infection or reactivation hypothesis. Larger studies including further virological, immunological and epidemiologic data are needed to understand the mechanisms of these recurrences.

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Conflict of interest statement

Declaration of Competing Interest None of the authors has any conflict of interest to declare regarding this subject. This work had no financial support.

Comment in

References

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