Toxin-Mediated siRNA Delivery

Spencer Zhao¹, Jeffrey M Karp², Nitin Joshi³

Affiliations

¹ Center for Nanomedicine and Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
² Center for Nanomedicine and Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA; Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: jmkarp@bwh.harvard.edu.
³ Center for Nanomedicine and Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address: njoshi@bwh.harvard.edu.

PMID: 32620268
DOI: 10.1016/j.tips.2020.06.006

Comment

Toxin-Mediated siRNA Delivery

Spencer Zhao et al. Trends Pharmacol Sci. 2020 Aug.

. 2020 Aug;41(8):511-513.

doi: 10.1016/j.tips.2020.06.006. Epub 2020 Jun 30.

Authors

Spencer Zhao¹, Jeffrey M Karp², Nitin Joshi³

Affiliations

¹ Center for Nanomedicine and Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
² Center for Nanomedicine and Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA; Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: jmkarp@bwh.harvard.edu.
³ Center for Nanomedicine and Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address: njoshi@bwh.harvard.edu.

PMID: 32620268
DOI: 10.1016/j.tips.2020.06.006

Abstract

AB toxins with built-in cell targeting and endosomal escape mechanisms are attractive intracellular delivery vehicles. However, their compatibility with nucleic-acid-based therapeutics is not fully explored. Arnold et al. demonstrated the first functional siRNA delivery by diphtheria toxin (DT) in vitro, marking an important step in expanding the utility of AB toxins for nucleic acid delivery.

Keywords: diphtheria toxin; glioblastoma; siRNA delivery.

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Comment on

Attenuated diphtheria toxin mediates siRNA delivery.
Arnold AE, Smith LJ, Beilhartz GL, Bahlmann LC, Jameson E, Melnyk RA, Shoichet MS. Arnold AE, et al. Sci Adv. 2020 May 1;6(18):eaaz4848. doi: 10.1126/sciadv.aaz4848. Print 2020 May. Sci Adv. 2020. PMID: 32917630 Free PMC article.

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Toxin-Mediated siRNA Delivery

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Toxin-Mediated siRNA Delivery

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