Let's talk about sex

Affiliations

Comment

James C Patti et al. Sci Immunol. 2020.

. 2020 Jul 3;5(49):eabd4828.

doi: 10.1126/sciimmunol.abd4828.

¹ Broad Institute of MIT and Harvard, Cambridge, MA, USA. Brigham and Women's Hospital, Boston, MA, USA. jpatti@broadinstitute.org gkgriffin@bwh.harvard.edu.

Abstract

Complement gene variation drives sex biases in autoimmune disease.

Complement genes contribute sex-biased vulnerability in diverse disorders.
Kamitaki N, Sekar A, Handsaker RE, de Rivera H, Tooley K, Morris DL, Taylor KE, Whelan CW, Tombleson P, Loohuis LMO; Schizophrenia Working Group of the Psychiatric Genomics Consortium; Boehnke M, Kimberly RP, Kaufman KM, Harley JB, Langefeld CD, Seidman CE, Pato MT, Pato CN, Ophoff RA, Graham RR, Criswell LA, Vyse TJ, McCarroll SA. Kamitaki N, et al. Nature. 2020 Jun;582(7813):577-581. doi: 10.1038/s41586-020-2277-x. Epub 2020 May 11. Nature. 2020. PMID: 32499649 Free PMC article.