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. 2020 Sep;17(9):992-994.
doi: 10.1038/s41423-020-0492-x. Epub 2020 Jul 3.

Elevated serum levels of S100A8/A9 and HMGB1 at hospital admission are correlated with inferior clinical outcomes in COVID-19 patients

Liting Chen #  1 , Xiaolu Long #  1 , Qian Xu #  1 , Jiaqi Tan #  2 , Gaoxiang Wang  1 , Yang Cao, Jia Wei  1 , Hui Luo  1 , Hui Zhu  3 , Liang Huang  1 , Fankai Meng  1 , Lifang Huang  1 , Na Wang  1 , Xiaoxi Zhou  1 , Lei Zhao  1 , Xing Chen  1 , Zekai Mao  1 , Caixia Chen  1 , Zhen Li  3 , Ziyong Sun  4 , Jianping Zhao  5 , Daowen Wang  6 , Gang Huang  7 , Wei Wang  8 , Jianfeng Zhou  9
Affiliations

Elevated serum levels of S100A8/A9 and HMGB1 at hospital admission are correlated with inferior clinical outcomes in COVID-19 patients

Liting Chen et al. Cell Mol Immunol. 2020 Sep.
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Serum levels of S100A8/A9 and HMGB1 were strongly correlated with the severity of clinical manifestations and with great predictive power for the risk for ICU admission and death. a, b Comparison of S100A8/A9 and HMGB1 levels between healthy people, non-ICU patients, and ICU patients of COVID-19. c, d Comparison of S100A8/A9 and HMGB1 levels between healthy people, alive patients and dead patients of COVID-19. Spearman’s correlation analyses between S100A8/A9 or HMGB1 levels and peak CT score (e, f), D-dimer level (g, h), neutrophil/lymphocyte ratio (i, j), and quick Sequential Organ Failure Assessment (qSOFA) scores (k, l). m, n Spearman’s correlation analyses of S100A8/A9 or HMGB1 and COVID-GRAM risk score. o, p Comparison of S100A8/A9 or HMGB1 between healthy people and COVID-19 patients of different risk groups (divided according to COVID-GRAM risk score). q, r Receiver operating characteristic (ROC) curve evaluation of the performance of S100A8/A9, HMGB1, combined S100A8/A9 and HMGB1, and COVID-GRAM risk score in distinguish COVID-19 patients with ICU admission or subsequent death. Sixty days survival is shown for patients with different circulating S100A8/A9 levels (s) and different COVID-GRAM risks (t) by Kaplan–Meier curves
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