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Review
. 2020 Jul 24;23(7):101303.
doi: 10.1016/j.isci.2020.101303. Epub 2020 Jun 20.

Current Status of COVID-19 Therapies and Drug Repositioning Applications

Ozlem Altay  1 , Elyas Mohammadi  2 , Simon Lam  3 , Hasan Turkez  4 , Jan Boren  5 , Jens Nielsen  6 , Mathias Uhlen  1 , Adil Mardinoglu  7
Affiliations
Review

Current Status of COVID-19 Therapies and Drug Repositioning Applications

Ozlem Altay et al. iScience. .

Abstract

The rapid and global spread of a new human coronavirus (SARS-CoV-2) has produced an immediate urgency to discover promising targets for the treatment of COVID-19. Drug repositioning is an attractive approach that can facilitate the drug discovery process by repurposing existing pharmaceuticals to treat illnesses other than their primary indications. Here, we review current information concerning the global health issue of COVID-19 including promising approved drugs and ongoing clinical trials for prospective treatment options. In addition, we describe computational approaches to be used in drug repurposing and highlight examples of in silico studies of drug development efforts against SARS-CoV-2.

Keywords: Health Sciences; Medicine.

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Conflict of interest statement

Declaration of Interests The authors declare no personal conflict of interests.

Figures

Figure 1
Figure 1
Deadliest Pandemics and Outbreaks in Recorded History Left: Pandemic clock, a comprehensive illustration of the most deadly pandemics through the history sorted by date. Right: Pandemic outbreaks and natural reservoir hosts sorted by the number of mortalities. In some outbreaks, the exact duration is not precisely determined (ND) because the outbreak died out and recurred multiple times in the same region and era.
Figure 2
Figure 2
Procedure of Care for Patients with COVID-19, Including Common Symptoms, Comorbidities, Aggravating Factors, Laboratory-Based Tests, and Candidate Treatments
See this image and copyright information in PMC

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