Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2020 Sep;45(9):726-728.
doi: 10.1016/j.tibs.2020.06.008. Epub 2020 Jul 1.

Phase Separation of RNA Helicase Triggers Stress-Responsive Translational Switch

Jogender Singh  1
Affiliations
Comment

Phase Separation of RNA Helicase Triggers Stress-Responsive Translational Switch

Jogender Singh. Trends Biochem Sci. 2020 Sep.

Abstract

A swift response to stress requires global translational suppression, excepting stress proteins. Recently, Iserman et al. uncovered that stress-induced phase separation of the RNA helicase Ded1p results in translational suppression of housekeeping transcripts that contain complex 5' untranslated regions (UTRs). Stress-response transcripts with simpler 5' UTRs escape this global translational suppression.

Keywords: RNA helicase; phase separation; stress granules; stress response; untranslated regions.

PubMed Disclaimer

Comment on

Publication types

LinkOut - more resources