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Case Reports
. 2020 Dec;158(6):e267-e268.
doi: 10.1016/j.chest.2020.06.049. Epub 2020 Jul 3.

Systemic Capillary Leak Syndrome Secondary to Coronavirus Disease 2019

Robert Case  1 , Aliaksandr Ramaniuk  1 , Pamela Martin  1 , Paul J Simpson  1 , Christopher Harden  1 , Ali Ataya  2
Affiliations
Case Reports

Systemic Capillary Leak Syndrome Secondary to Coronavirus Disease 2019

Robert Case et al. Chest. 2020 Dec.

Abstract

Systemic capillary leak syndrome is a rare disorder characterized by dysfunctional inflammatory response, endothelial dysfunction, and extravasation of fluid from the vascular space to the interstitial space leading to shock, hemoconcentration, hypoalbuminemia, and subsequent organ failure. The condition may be idiopathic or secondary to an underlying cause, which can include viral infections. Here we describe a patient with acute coronavirus disease 2019 (COVID-19) infection who presented with hemoconcentration, shock, and hypoalbuminemia. The patient subsequently developed rhabdomyolysis and compartment syndrome of all four extremities, requiring fasciotomies. This is the first reported case of systemic capillary leak syndrome associated with COVID-19 infection. This case adds to the evolving spectrum of inflammatory effects associated with this viral infection.

Keywords: COVID-19; capillary leak; shock; systemic capillary leak syndrome.

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Comment in

  • Clarkson's Disease Episode or Secondary Systemic Capillary Leak-Syndrome: That Is the Question!
    Pineton de Chambrun M, Constantin JM, Mathian A, Quemeneur C, Lepere V, Combes A, Luyt CE, Amoura Z. Pineton de Chambrun M, et al. Chest. 2021 Jan;159(1):441. doi: 10.1016/j.chest.2020.07.084. Chest. 2021. PMID: 33422212 Free PMC article. No abstract available.
  • Response.
    Ataya A, Case R, Harden C. Ataya A, et al. Chest. 2021 Jan;159(1):442. doi: 10.1016/j.chest.2020.08.2045. Chest. 2021. PMID: 33422213 Free PMC article. No abstract available.

References

    1. Clarkson B., Thompson D., Horwith M., Luckey E. Cyclical edema and shock due to increased capillary permeability. Am J Med. 1960;29:193–216. - PubMed
    1. Druey K., Greipp P. Narrative review: the systemic capillary leak syndrome. Ann Intern Med. 2010;153:90–98. - PMC - PubMed
    1. Ebdrup L., Druey K.M., Druey K., Mogensen T. Severe capillary leak syndrome with cardiac arrest triggered by influenza virus infection. BMJ Case Rep. 2018 doi: 10.1136/bcr-2018-226108. - DOI - PMC - PubMed
    1. Dhir V., Arya V., Malav I. Idiopathic systemic capillary leak syndrome (SCLS): case report and systemic review of cases reported in the last 16 years. Intern Med. 2007;46(12):899. - PubMed
    1. Kapoor P., Greipp P., Schaefer E. Idiopathic systemic capillary leak syndrome (Clarkson’s disease): the Mayo Clinic experience. Mayo Clin Proc. 2010;85(10):905–912. - PMC - PubMed

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