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. 1988 May 15;252(1):309-12.
doi: 10.1042/bj2520309.

Human recombinant interleukin-1 regulates cellular mRNA levels of dermatan sulphate proteoglycan core protein

J Heino  1 , V M Kähäri, A Mauviel, T Krusius
Affiliations

Human recombinant interleukin-1 regulates cellular mRNA levels of dermatan sulphate proteoglycan core protein

J Heino et al. Biochem J. .

Abstract

Human skin fibroblasts were exposed to various concentrations (from 0.01 to 5.0 units/ml) of human recombinant interleukin-1 alpha and interleukin-1 beta (IL-1 alpha and IL-1 beta). Both IL-1 alpha and IL-1 beta were found to increase dermatan-sulphate-proteoglycan (DSPG) core-protein mRNA levels. Maximal increase (3.0-fold) was seen at 48 h after addition of 1 unit of IL-1 beta/ml. In spite of the elevated DSPG-core-protein mRNA only a slight increase (from 10 to 18%) could be seen in the production of DSPG to cell-culture medium. No changes in the molecular mass of DSPG could be detected.

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