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. 2020 Oct;36(10):725-727.
doi: 10.1016/j.tig.2020.06.003. Epub 2020 Jul 2.

Is CpG Density the Link between Epigenetic Aging and Lifespan?

Emily M Bertucci  1 , Benjamin B Parrott  2
Affiliations

Is CpG Density the Link between Epigenetic Aging and Lifespan?

Emily M Bertucci et al. Trends Genet. 2020 Oct.

Abstract

The genetic mechanisms contributing to lifespan variation remain unresolved. Based on recent conceptual advances in our understanding of epigenetic potential and the relocalization of chromatin modifiers (RCM), we hypothesize that increased CpG density is protective against age-related erosion of the epigenetic landscape and may explain interspecific variation in lifespan.

Keywords: DNA methylation; epigenetic aging; epigenetic potential; lifespan.

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