Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Apr 1;17(4):e05641.
doi: 10.2903/j.efsa.2019.5641. eCollection 2019 Apr.

Safety and efficacy of Hemicell®-L (endo-1,4-β-mannanase) as a feed additive for chickens for fattening or reared for laying, turkeys for fattening or reared for breeding and minor poultry species

EFSA Panel on Additives and Products or Substances used in Animal Feed (EFSA FEEDAP Panel); Vasileios Bampidis, Giovanna Azimonti, Maria de Lourdes Bastos, Henrik Christensen, Birgit Dusemund, Maryline Kouba, Mojca Kos Durjava, Marta López-Alonso, Secundino López Puente, Francesca Marcon, Baltasar Mayo, Alena Pechová, Mariana Petkova, Fernando Ramos, Yolanda Sanz, Roberto Edoardo Villa, Ruud Woutersen, Paul Brantom, Pier Sandro Cocconcelli, Noël Albert Dierick, Boet Glandorf, Lieve Herman, Guido Rychen, Maria Saarela, Jaime Aguilera, Montserrat Anguita

Safety and efficacy of Hemicell®-L (endo-1,4-β-mannanase) as a feed additive for chickens for fattening or reared for laying, turkeys for fattening or reared for breeding and minor poultry species

EFSA Panel on Additives and Products or Substances used in Animal Feed (EFSA FEEDAP Panel) et al. EFSA J. .

Abstract

The additive Hemicell®-L is a liquid preparation of endo-1,4-β-mannanase that is authorised as a zootechnical feed additive for chickens for fattening. The applicant has requested the renewal of the authorisation, new uses and the modification of the manufacturing process including the change of the production strain. The new production strain is a genetically modified strain of Paenibacillus lentus obtained from a strain that has been evaluated previously by EFSA and considered to be safe. The EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) evaluated the genetic modification and concluded that the sequences introduced to obtain the production strain did not raise safety concerns. The production strain and its DNA were not detected in the additive. The Panel concluded that the additive is safe for chickens for fattening and turkeys for fattening at the recommended level. These conclusions were extended or extrapolated to the other target species under application. The Panel concluded that the results obtained in the toxicological studies performed with the fermentation products of the recipient strain and of another genetically modified strain obtained from the same recipient strain could support the safety for the consumer of the product obtained with the new production strain. The additive is not a dermal or eye irritant and it is not a dermal sensitiser. However, considering that the active substance is a protein, the additive should be regarded as a potential sensitiser. The Panel concluded that the additive has a potential to be efficacious as a zootechnical additive for the target species at 79,200 U/kg.

Keywords: 4‐β‐mannanase; digestibility enhancers; efficacy; endo‐1; poultry; safety; zootechnical additives.

PubMed Disclaimer

References

    1. EFSA (European Food Safety Authority), 2006. Opinion of the Scientific Panel on Additives and Products or Substances used in Animal Feed on the safety and efficacy of the enzymatic preparation Hemicell® Feed Enzyme (β‐D‐mannanase) as a feed additive for chickens for fattening in accordance with Regulation (EC) No 1831/2003. EFSA Journal 2006;4(11):412, 12 pp. 10.2903/j.efsa.2006.412 - DOI
    1. EFSA (European Food Safety Authority), 2008a. Technical Guidance of the Scientific Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) for assessing the safety of feed additives for the environment. EFSA Journal 2008;6(10):842, 28 pp. 10.2903/j.efsa.2008.842 - DOI
    1. EFSA (European Food Safety Authority), 2008b. Technical Guidance: Microbial Studies. EFSA Journal 2008;6(10):836, 3 pp. 10.2903/j.efsa.2008.836 - DOI
    1. EFSA (European Food Safety Authority), 2008c. Technical Guidance: Extrapolation of data from major species to minor species regarding the assessment of additives for use in animal nutrition. EFSA Journal 2008;6(9):803, 5 pp. 10.2903/j.efsa.2008.803 - DOI
    1. EFSA FEEDAP Panel (EFSA Panel on Additives and Products or Substances used in Animal Feed), 2011. Technical guidance: Tolerance and efficacy studies in target animals. EFSA Journal 2011;9(5):2175, 15 pp. 10.2903/j.efsa.2011.2175 - DOI

LinkOut - more resources